FBP1 expression is associated with basal-like breast carcinoma

Oncology Letters
Lei ShiQingyuan Zhang

Abstract

The present study aimed to investigate the value of liver fructose 1,6-bisphophatase (FBP1) and hypoxia-inducible factor-1α (HIF-1α) in the molecular subtyping of breast carcinoma. Tissue obtained from 60 surgical specimens from patients with breast carcinoma underwent immunohistochemical staining for cytokeratin 5/6, HIF-1α and FBP1. The variation in the expression levels of these markers and clinicopathological factors were compared between molecular subtypes. In addition, disease-free survival was compared between basal-like and luminal breast carcinoma, according to differing expression levels of HIF-1α and FBP1. The results revealed that HIF-1α expression was detectable in 20/60 (33.3%) of the breast carcinoma cases, and was positively associated with lymph node metastasis (P=0.007). HIF-1α-positive patients exhibited a shorter disease-free survival, compared with HIF-1α-negative patients with invasive breast cancer. The expression levels of FBP1 were positive in 33/60 tumor tissues (55%; P<0.001), and FBP1 expression was associated with nuclear grade (P=0.017) and tumor stage (P=0.012). In breast carcinoma, HIF-1α expression levels were significantly negatively correlated with FBP1 levels (r=-0.711; P<0.001). Cox regressi...Continue Reading

References

Jan 1, 1987·Cancer Metastasis Reviews·J E Moulder, S Rockwell
Dec 1, 1970·British Journal of Cancer·S V Bhide
Aug 17, 1999·Annual Review of Nutrition·R C NordlieA J Lange
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W JacobsS J Schnitt
May 23, 2000·Critical Reviews in Biochemistry and Molecular Biology·G L Semenza
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Sep 7, 2001·Diabetes/metabolism Research and Reviews·J Radziuk, S Pye
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Oct 16, 2002·The Journal of Biological Chemistry·Elisabeth L PagéDarren E Richard
May 13, 2003·Molecular Cancer·Manfred Kunz, Saleh M Ibrahim
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Giuseppe Viale
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandra GiatromanolakiEfthimios Sivridis
Dec 14, 2004·The Oncologist·Peter Vaupel
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Jean-Philippe DalesColette Charpin
Oct 4, 2005·Journal of Molecular Histology·A GizakA Dzugaj
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chad A LivasyCharles M Perou
Mar 24, 2006·Breast Cancer Research and Treatment·Sebastian F SchoppmannPeter Birner
May 26, 2006·Nature·Jacques PouysségurNathalie M Mazure
Sep 7, 2007·Breast Cancer Research and Treatment·Yutaka YamamotoHirotaka Iwase
Oct 22, 2008·Biochemical and Biophysical Research Communications·Marina BiglKlaus Eschrich
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emad A RakhaIan O Ellis
Jul 22, 2014·Nature·Bo LiM Celeste Simon

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Citations

Mar 21, 2018·Cancer Cell International·Gao-Min Liu, Yao-Ming Zhang
Mar 14, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Z ZhaoY Zhu

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Methods Mentioned

BETA
light microscopy
immunoprecipitation

Software Mentioned

SPSS

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