FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hidetaka AritaHideki Nakayama

Abstract

FBXW7 (F-box and WD repeat domain containing-7) is a tumor suppressor protein that regulates the degradation of various oncoproteins in several malignancies. However, limited information is available regarding FBXW7 expression in oral squamous cell carcinoma. Therefore, this study aimed to determine the clinical significance of FBXW7 expression in oral squamous cell carcinoma. The FBXW7 expression patterns in oral squamous cell carcinoma and adjacent normal tissues from 15 patients who underwent radical resection were evaluated using quantitative real-time polymerase chain reaction and immunohistochemical staining. In addition, immunohistochemistry was performed using paraffin-embedded sections from biopsy specimens obtained from 110 patients with oral squamous cell carcinoma who underwent surgery after 5 fluorouracil-based chemoradiotherapy. The associations of FBXW7 expression with various clinicopathological features and prognosis were evaluated in these patients. As a results, in the 15 matched samples, the FBXW7 expression was significantly decreased in the oral squamous cell carcinoma tissues compared to that in the adjacent normal tissues. In the clinicopathological analysis, compared to high protein expression, low FBXW...Continue Reading

References

Jul 20, 2005·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Marc L CohenJack A Yanovski
Oct 3, 2007·Cancer Research·Shahab AkhoondiCharles Spruck
Jun 11, 2008·Cancer Letters·YingMeei TanCharles Spruck
Aug 5, 2008·Oral Oncology·Jatin P Shah, Ziv Gil
Apr 16, 2009·Cancer Research·Takehiko YokoboriMasaki Mori
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Masaaki IwatsukiMasaki Mori
Oct 2, 2009·Haematologica·Claudia D BaldusWolf-Karsten Hofmann
May 25, 2011·Oncotarget·Hiroyuki InuzukaWenyi Wei
Oct 19, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Zhiwei WangWenyi Wei
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 23, 2013·Cancer Cell·Shoichiro TakeishiKeiichi I Nakayama
Jul 31, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan TheysMarc Vooijs
Aug 14, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ryoji YoshidaTakaaki Ito
Nov 20, 2014·Cancer Prevention Research·Evgeny IzumchenkoDavid Sidransky
Mar 10, 2015·Translational Oncology·Dongping WeiMeredith A Morgan
Mar 10, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ye XuGe Lou
Apr 26, 2016·Molecular Therapy. Methods & Clinical Development·Federica LorenziAbdolrahman S Nateri
Apr 27, 2016·Cancer Science·Shoichiro Takeishi, Keiichi I Nakayama

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Citations

Feb 23, 2019·Cancers·Bethsebie Lalduhsaki SailoAjaikumar Bahulayan Kunnumakkara
Oct 22, 2020·Molecular Biology Reports·Keerthana Karunakaran, Rajiniraja Muniyan
Dec 27, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Linzhi YanXueqiong Zhu

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Methods Mentioned

BETA
biopsy
reverse transcription PCR

Software Mentioned

JMP

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