Fcγ and Complement Receptors and Complement Proteins in Neutrophil Activation in Rheumatoid Arthritis: Contribution to Pathogenesis and Progression and Modulation by Natural Products

Evidence-based Complementary and Alternative Medicine : ECAM
Adriana Balbina Paoliello-PaschoalatoYara M Lucisano-Valim

Abstract

Rheumatoid arthritis (RA) is a highly disabling disease that affects all structures of the joint and significantly impacts on morbidity and mortality in RA patients. RA is characterized by persistent inflammation of the synovial membrane lining the joint associated with infiltration of immune cells. Eighty to 90% of the leukocytes infiltrating the synovia are neutrophils. The specific role that neutrophils play in the onset of RA is not clear, but recent studies have evidenced that they have an important participation in joint damage and disease progression through the release of proteolytic enzymes, reactive oxygen species (ROS), cytokines, and neutrophil extracellular traps, in particular during frustrated phagocytosis of immune complexes (ICs). In addition, the local and systemic activation of the complement system contributes to the pathogenesis of RA and other IC-mediated diseases. This review discusses (i) the participation of Fcγ and complement receptors in mediating the effector functions of neutrophils in RA; (ii) the contribution of the complement system and ROS-dependent and ROS-independent mechanisms to joint damage in RA; and (iii) the use of plant extracts, dietary compounds, and isolated natural compounds in the ...Continue Reading

References

Apr 1, 1975·Annals of the Rheumatic Diseases·L SolomonH A Valkenburg
Jan 1, 1988·International Journal of Immunopharmacology·W EnglbergerM J Parnham
Mar 1, 1987·The Journal of Clinical Investigation·P M Henson, R B Johnston
Jun 6, 1974·The New England Journal of Medicine·S Ruddy, H R Colten
Jan 1, 1993·Arthritis and Rheumatism·W W ChathamW D Blackburn
Mar 21, 1993·Biochimica Et Biophysica Acta·H IwamuraD A Willoughby
Mar 1, 1997·Arthritis and Rheumatism·S SadallahJ A Schifferli
Nov 20, 1998·Biological & Pharmaceutical Bulletin·K Y JungH K Lee
Jun 5, 1999·International Journal of Clinical & Laboratory Research·D CaccavoA Afeltra
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B T Wipke, P M Allen
Oct 9, 2001·European Journal of Clinical Investigation·G FossatiS W Edwards
Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
Apr 16, 2002·Arthritis and Rheumatism·Elena NeumannUlf Müller-Ladner
Nov 21, 2002·Biochemical Society Transactions·R A Smith
Feb 21, 2003·Annals of the Rheumatic Diseases·L SköldstamG Johansson
Feb 25, 2003·Current Opinion in Rheumatology·E Ernst
Apr 11, 2003·Arthritis and Rheumatism·Damini JawaheerUNKNOWN North American Rheumatoid Arthritis Consortium
May 16, 2003·Nature·Gary S Firestein
Nov 14, 2003·Microbes and Infection·Mikkel Faurschou, Niels Borregaard
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shivani JaswalJasbinder Kaur
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Nov 13, 2004·Arthritis Research & Therapy·Carol A Hitchon, Hani S El-Gabalawy
Jan 5, 2005·Trends in Immunology·Sonia Jancar, Mariano Sánchez Crespo
Jul 1, 2005·Arthritis Research & Therapy·Samuel SolomonHarald Illges
Aug 9, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kristina BelostockiLuminita Pricop
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Salahuddin AhmedTariq M Haqqi
Sep 6, 2005·Cell Biochemistry and Function·Gülden BaskolMuzaffer Ustdal

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Citations

Mar 24, 2017·Environmental Science and Pollution Research International·Priyanka Prasad, Dona Sinha
Aug 14, 2020·Immunological Investigations·Leia SenaFabiana Antunes Andrade
Dec 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lucinéia Reuse AlbieroYara Maria Lucisano-Valim
Oct 3, 2020·Inflammopharmacology·Alireza HejratiParisa Zafari
Jan 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Diego Pinto de OliveiraFernão Castro Braga

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Methods Mentioned

BETA
glycosylation
nuclear translocation
bronchoalveolar
lavage

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