Fc receptor-like 3 (-169T>C) polymorphism increases the risk of tendinopathy in volleyball athletes: a case control study.

BMC Medical Genetics
José Inácio SallesJamila Alessandra Perini

Abstract

Tendinopathy pathogenesis is associated with inflammation. Regulatory T (Treg) cells contribute to early tissue repair through an anti-inflammatory action, with the forkhead box P3 (FOXP3) transcription factor being essential for Treg function, and the FC-receptor-like 3 (FCRL3) possibly negatively regulating Treg function. FCRL3 -169T>C and FOXP3 -2383C>T polymorphisms are located near elements that regulate respective genes expression, thus it was deemed relevant to evaluate these polymorphisms as risk factors for tendinopathy development in athletes. This case-control study included 271 volleyball athletes (146 tendinopathy cases and 125 controls) recruited from the Brazilian Volleyball Federation. Genotyping analyses were performed using TaqMan assays, and the association of the polymorphisms with tendinopathy evaluated by multivariate logistic regression. Tendinopathy frequency was 63% patellar, 22% rotator cuff and 15% Achilles tendons respectively. Tendinopathy was more common in men (OR = 2.87; 95% CI = 1.67-4.93). Higher age (OR = 8.75; 95% CI = 4.33-17.69) and more years of volleyball practice (OR = 8.38; 95% CI = 3.56-19.73) were risk factors for tendinopathy. The FCRL3 -169T>C frequency was significantly different b...Continue Reading

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Citations

Sep 4, 2019·BMC Medical Genetics·Umile Giuseppe LongoVincenzo Denaro
Feb 26, 2020·BMC Musculoskeletal Disorders·Rodrigo Araújo GoesJamila Alessandra Perini
May 15, 2021·BMC Sports Science, Medicine and Rehabilitation·Lucas Rafael LopesJamila Alessandra Perini
Feb 20, 2021·Medicine and Science in Sports and Exercise·Stuart K KimGeoffrey D Abrams
Jun 4, 2021·Medicine and Science in Sports and Exercise·Stuart K KimGeoffrey D Abrams
Mar 6, 2021·The Journal of Sports Medicine and Physical Fitness·Hugo-Henrique SilvaRui Medeiros

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Methods Mentioned

BETA
genotyping

Software Mentioned

Epi
Info
Statistical Package for Social Sciences ( SPSS

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