PMID: 9651790Jan 1, 1997Paper

Fc receptors as targets for immunotherapy

International Reviews of Immunology
H RouardJ L Teillaud

Abstract

Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxicity, or cytokine or inflammatory mediator release, make them potential targets for immuno-intervention. In the present review, we will describe how membrane and soluble human Fc epsilon R and Fc gamma R have been already used as targets/tools for immuno-interventions by using monoclonal and bispecific engineered antibodies. Some therapeutic uses of these molecules both in cancer, infectious, and auto-immune diseases are presented.

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Citations

Feb 13, 2010·Protein Engineering, Design & Selection : PEDS·Jeff L EllsworthCarl Birks
Apr 1, 2014·Journal of Clinical Immunology·Hicham BouhlalSrini V Kaveri
Jan 27, 2010·Cancer Science·Koichi InamiOkio Hino
Dec 11, 2019·Antibodies·Mark L ChiuGary L Gilliland
Nov 12, 2003·The Journal of Biological Chemistry·Patrick MaillardAgata Budkowska
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jagadeesh BayrySrini V Kaveri

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