PMID: 7541388Jul 1, 1995Paper

Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2)

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S S AhmedH Shirasawa

Abstract

In systemic lupus erythematosus accompanied by the abnormal appearance of circulating immune complexes (ICs), Fc gamma receptor (FcR)-mediated IC handling in macrophages including Kupffer cells has been shown previously. However, sinusoidal endothelial cells (SECs) largely ingest soluble immunoglobulin (Ig) G-ICs through FcRs. In this study, the character, antigenic expression, and activity (i.e., ligand-binding capacity of SEC FcRs in NZB/NZW F1 lupus and NZW nonautoimmune mice) were immunohistochemically analyzed using monoclonal antibody (MAb) 2.4G2 to FcRs and peroxidase-antiperoxidase IgG as a ligand on cryosections. MAb 2.4G2 stained SECs and blocked the ligand binding of SEC FcRs in both mice strains. The staining intensities with MAb 2.4G2 in SECs and the FcR activities in SECs alone and all sinusoidal cells in both mice strains reached their maximum values at the age of 5 months. Staining intensities in NZB/W F1 were significantly higher at 1 and 2 months and lower at 9 months than those in NZW. The number of Kupffer cells detected by MAb F4/80 to macrophages in both mice strains gradually increased until 5 months, but their number in NZB/W F1 at 9 months was twice as large as that in NZW. In conclusion, SEC FcRs in mi...Continue Reading

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Citations

Aug 3, 2001·Cell Biology International·T Løvdal, T Berg
Feb 3, 2006·The Journal of Clinical Investigation·Varsha KumarJ Engelbert Gessner
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S G Hübscher
Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·A H BirnbaumN S LeLeiko
Oct 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Latha P GanesanClark L Anderson
Feb 12, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·James M TurmanLatha P Ganesan

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