Fc receptors on rabbit lymphocytes. Identification and organ distribution of rosette-forming cells; cocapping with surface immunoglobulin

European Journal of Immunology
B J BastR E Ballieux

Abstract

Fc receptor (FcR)-bearing cells were demonstrated using ox erythrocytes coated with homologous IgG-type antibodies (EA gamma) in rabbit peripheral blood leukocytes (PBL) and in various lymphoid organs. Discrimination of the rosette-forming cells (RFC) is carried out after prior ingestion of tetramethylrhodamine isothiocyanate-labeled latex particles and in transmission electron microscopic studies. Most of the nonlymphoid cells (5-10%) in PBL and spleen cell suspensions expose FcR. These nonlymphoid cells are almost absent in other lymphoid organs, except in bone marrow. The average percentage of cells rosetting with IgG-sensitized erythrocytes (EA gamma RFC) in lymphoid cell preparations of the various tissues was as follows: PBL 25%, bone marrow 65%, appendix 37%, spleen 40%, Peyer's patches 44%, thymus 2% and peripheral lymph node 27%. The nature of FcR-bearing PBL was further studied using F (ab')2 anti-IgM, anti-IgA or anti-T cell conjugates. About half of the population of B cells, bearing IgM or IgA express FcR. Moreover, about 80% of the RFC are found within the B cell population. Only a few T cells were found rosetting with EA gamma suggesting that most of the non-B lymphoid RFC are "null" cells. In different lymphoid ...Continue Reading

References

May 1, 1978·European Journal of Immunology·F Loor, A S Kelus
Feb 1, 1977·Cellular Immunology·C T ChouS Dubiski
Jan 1, 1978·Contemporary Topics in Immunobiology·L MorettaM D Cooper
Dec 1, 1979·European Journal of Immunology·B J BastR E Ballieux
Jan 1, 1976·Scandinavian Journal of Immunology·P H Krammer, B Pernis
Jan 1, 1976·Scandinavian Journal of Immunology·F Gmelig-MeylingR E Ballieux
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Nov 18, 1976·Nature·A A Nash, N R Ling
Feb 6, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·W LeeneC van Steeg
Jan 1, 1980·Acta paediatrica Scandinavica·F Gmelig-MeylingR E Ballieux

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