Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

European Journal of Human Genetics : EJHG
Virginia De RoseAlberto Piazza

Abstract

It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcgamma receptor II (FcgammaRII) is involved in host defense against microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF. We studied 167 Italian unrelated patients with CF and 50 control subjects. The distribution of FcgammaRIIA genotypes in CF patients was compared with that in control subjects and the different genotypes were related with the presence or absence of P. aeruginosa infection and markers of disease severity in CF patients. The distribution of FcgammaRIIA genotypes was not significantly different between CF patients and controls. We observed that in CF patients with the same CFTR genotype (DeltaF508/DeltaF508), those carrying the R allele of FcgammaRIIA had an increased risk of acquiring chronic P. aeruginosa infection (P=0.042, R.R.: 4.38; 95% CI: 1.17/22.4). Moreover, the frequency of R/R genotype in patients with chronic P. aeruginosa infection seems to be higher than that of control subjects and patients without chronic ...Continue Reading

References

Jul 1, 1990·The Journal of Experimental Medicine·P A WarmerdamP J Capel
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G A PeltzK W Moore
Apr 24, 1993·Lancet·C Koch, N Høiby
May 1, 1993·Immunology Today·J G van de Winkel, P J Capel
Mar 1, 1996·The Journal of Clinical Investigation·J E SalmonR P Kimberly
Jan 1, 1996·European Journal of Human Genetics : EJHG·B Kerem, E Kerem
Jan 1, 1995·Annual Review of Genetics·J Zielenski, L C Tsui
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·P B DavisM W Konstan
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B PierT S Zaidi
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·Y AronD Hubert
Dec 6, 2000·The European Respiratory Journal·G DöringD J Touw
Jan 29, 2002·The American Journal of Medicine·Pere DomingoGuillermo Vázquez
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

❮ Previous
Next ❯

Citations

Jan 6, 2006·The New England Journal of Medicine·Frauke StankeTim Becker
Sep 25, 2008·Current Opinion in Pulmonary Medicine·Joseph M Collaco, Garry R Cutting
Apr 8, 2010·Science Translational Medicine·Yoriko SaitoFumihiko Ishikawa
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Garry R Cutting
Feb 27, 2014·The International Journal of Biochemistry & Cell Biology·Loic GuillotHarriet Corvol
Nov 26, 2008·Paediatric Respiratory Reviews·Siobhain Brennan
Jun 6, 2009·Clinical and Vaccine Immunology : CVI·Henrik EndemanDouwe H Biesma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.