FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

Immunity
A Ioan-FacsinayJ S Verbeek

Abstract

The high-affinity receptor for IgG, FcgammaRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcgammaRIII and complement factors, hampering the definition of its biological role. Moreover, in vivo, FcgammaRI is occupied by monomeric IgG2a, reducing its accessibility to newly formed IgG2a-IC. By using a variety of FcgammaR(-/-) mice, we demonstrate that in the absence of FcgammaRI, the IgG2a-IC-induced cellular processes of phagocytosis, cytokine release, cellular cytotoxicity, and antigen presentation are impaired. FcgammaRI(-/-) mice showed impaired hypersensitivity responses, strongly reduced cartilage destruction in an arthritis model, and impaired protection from a bacterial infection. We conclude that FcgammaRI contributes substantially to a variety of IgG2a-IC-dependent immune functions and immunopathological responses.

References

Dec 1, 1975·The Journal of Experimental Medicine·J C Unkeless, H N Eisen
Jan 1, 1991·Annual Review of Immunology·J V Ravetch, J P Kinet
Mar 1, 1994·International Immunology·S Sanderson, N Shastri
Jun 2, 1997·The Journal of Experimental Medicine·F S SutterwalaD M Mosser
Mar 14, 1998·Research in Immunology·J S VerbeekJ G van de Winkel
Jul 7, 1998·The Journal of Experimental Medicine·F S SutterwalaD M Mosser
Nov 27, 1999·FEMS Immunology and Medical Microbiology·S M HellwigF R Mooi
Jun 14, 2000·Journal of Virology·M MeiteJ P Coutelier
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Jul 11, 2001·Microbes and Infection·K H Mills
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·R S DavisM D Cooper

❮ Previous
Next ❯

Citations

Sep 6, 2006·Springer Seminars in Immunopathology·Lucie BaudinoShozo Izui
Oct 18, 2006·Springer Seminars in Immunopathology·Peter Boross, J Sjef Verbeek
Nov 23, 2006·Springer Seminars in Immunopathology·Falk Nimmerjahn
Nov 9, 2006·Springer Seminars in Immunopathology·Nicholas C van de VeldeP Mark Hogarth
Mar 3, 2005·Journal of Clinical Immunology·Toshiyuki Takai
Apr 15, 2004·Immunology Letters·Joël F G Cohen-SolalCatherine Sautès-Fridman
Nov 5, 2002·Current Opinion in Immunology·P Mark Hogarth
Aug 14, 2009·Expert Reviews in Molecular Medicine·Lisa C WillcocksMenna R Clatworthy
Jun 8, 2013·Cell Death and Differentiation·D HannaniL Zitvogel
Sep 9, 2008·Nature Immunology·Sho YamasakiTakashi Saito
Mar 31, 2012·Nature Reviews. Drug Discovery·P Mark Hogarth, Geoffrey A Pietersz
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Sep 13, 2003·Immunology and Cell Biology·Caroline Tan SardjonoP Mark Hogarth
Sep 13, 2003·Immunology and Cell Biology·Esther ReefmanMarc Bijl
Sep 13, 2003·Kidney International·Takayuki FujiiTakashi Saito
Jul 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey M BeekmanJeanette H W Leusen
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·A J M SchuerweghR E M Toes
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Falk NimmerjahnJeffrey V Ravetch
Jun 5, 2003·The Journal of Experimental Medicine·Jong-Dae JiLionel B Ivashkiv
Mar 8, 2006·The Journal of Experimental Medicine·Yasuhito HamaguchiThomas F Tedder
Aug 1, 2007·The Journal of Experimental Medicine·Hozefa S BandukwalaAnne I Sperling
Jan 30, 2008·Infection and Immunity·Atsuhiro MasudaTakeshi Azuma
Oct 24, 2003·Infection and Immunity·María Eugenia Rodriguez, W-Ludo van der Pol
Nov 22, 2005·Infection and Immunity·Eric YagerGary Winslow
Nov 28, 2007·Annual Review of Pathology·Hongwei GaoPeter A Ward
Nov 3, 2007·American Journal of Respiratory Cell and Molecular Biology·Lawrence M RheinCraig Gerard
Jul 3, 2002·The Journal of Clinical Investigation·Khadija RafiqRaphael Clynes
Feb 3, 2006·The Journal of Clinical Investigation·Varsha KumarJ Engelbert Gessner
Apr 12, 2012·Journal of Leukocyte Biology·Jeffrey R CrawfordRichard H Gomer
May 30, 2013·PloS One·Tanu ChawlaEng Eong Ooi
Jul 31, 2003·Journal of Periodontology·Shigehisa TanakaJohn G Tew

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.