FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

Immunity
Nadine BarnesP M Hogarth

Abstract

The inactivation of the mouse high-affinity IgG Fc receptor FcgammaRI resulted in a wide range of defects in antibody Fc-dependent functions. These studies showed the primary importance of FcgammaRI in endocytosis of monomeric IgG, kinetics, and extent of phagocytosis of immune complexes, in macrophage-based ADCC, and in immune complex-dependent antigen presentation to primed T cells. In the absence of FcgammaRI, antibody responses were elevated, implying the removal of a control point by the deletion of FcgammaRI. In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI. Thus, FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses.

References

Dec 1, 1975·The Journal of Experimental Medicine·J C Unkeless, H N Eisen
Mar 1, 1989·Immunology Today·M W FangerP M Guyre
Jan 1, 1984·European Journal of Immunology·M S SandrinI F McKenzie
Nov 1, 1993·The Journal of Experimental Medicine·C G Romball, W O Weigle
Jan 1, 1994·Advances in Immunology·M D Hulett, P M Hogarth
Nov 1, 1993·The Journal of Experimental Medicine·F L IerinoP M Hogarth
Jan 1, 1993·Methods in Enzymology·F Köntgen, C L Stewart
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L K ErnstC L Anderson
Oct 1, 1996·Immunity·D L Sylvestre, J V Ravetch
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R ClynesJ V Ravetch
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland

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Citations

Oct 27, 2009·Inflammatory Bowel Diseases·Andre BleichEdward H Leiter
Sep 6, 2006·Springer Seminars in Immunopathology·Lucie BaudinoShozo Izui
Nov 23, 2006·Springer Seminars in Immunopathology·Falk Nimmerjahn
Mar 3, 2005·Journal of Clinical Immunology·Toshiyuki Takai
Aug 16, 2008·Immunologic Research·Barbara J Vilen, Jennifer A Rutan
Apr 15, 2004·Immunology Letters·Andrew Getahun, Birgitta Heyman
Apr 15, 2004·Immunology Letters·Joël F G Cohen-SolalCatherine Sautès-Fridman
Jul 26, 2003·Immunology Letters·Birgitta Heyman
Nov 5, 2002·Current Opinion in Immunology·P Mark Hogarth
Mar 31, 2012·Nature Reviews. Drug Discovery·P Mark Hogarth, Geoffrey A Pietersz
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Sep 13, 2003·Immunology and Cell Biology·Caroline Tan SardjonoP Mark Hogarth
Sep 13, 2003·Immunology and Cell Biology·Esther ReefmanMarc Bijl
Sep 13, 2003·Kidney International·Takayuki FujiiTakashi Saito
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sven LétourneauOnur Boyman
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Falk NimmerjahnJeffrey V Ravetch
Jun 5, 2003·The Journal of Experimental Medicine·Jong-Dae JiLionel B Ivashkiv
May 7, 2003·The Journal of Experimental Medicine·Teresita Díaz de StåhlBirgitta Heyman
Mar 8, 2006·The Journal of Experimental Medicine·Yoshikatsu KanekoJeffrey V Ravetch
Aug 1, 2007·The Journal of Experimental Medicine·Hozefa S BandukwalaAnne I Sperling
Aug 1, 2007·The Journal of Experimental Medicine·Daisuke Kamimura, Michael J Bevan
Nov 22, 2005·Infection and Immunity·Eric YagerGary Winslow
Nov 28, 2007·Annual Review of Pathology·Hongwei GaoPeter A Ward
Nov 3, 2007·American Journal of Respiratory Cell and Molecular Biology·Lawrence M RheinCraig Gerard
May 25, 2007·Arthritis Research & Therapy·Sofia E MagnussonSandra Kleinau
May 30, 2013·PloS One·Tanu ChawlaEng Eong Ooi
May 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert BrodzikHilary Koprowski
Jul 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey M BeekmanJeanette H W Leusen
Nov 9, 2006·Springer Seminars in Immunopathology·Nicholas C van de VeldeP Mark Hogarth
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raymond E HulseRichard P Kraig
Feb 27, 2016·Signal Transduction and Targeted Therapy·Sasha BogdanovichJayakrishna Ambati
Apr 23, 2003·The American Journal of Pathology·Ruth M TarziH Terence Cook
Sep 8, 2009·Trends in Parasitology·Richard J Pleass, Jerzy M Behnke
Jan 22, 2008·Immunology Letters·Jeffrey M BeekmanJeanette H W Leusen
Feb 13, 2007·Current Opinion in Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Nov 25, 2005·Scandinavian Journal of Immunology·F HjelmB Heyman
Aug 21, 2009·Parasite Immunology·R J Pleass
Mar 3, 2004·Journal of Neuroscience Research·Alexander J Szalai, Scott R Barnum
Aug 22, 2006·Scandinavian Journal of Immunology·F HjelmB Heyman

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