FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ming ZhaoGunilla Nordin Fredrikson

Abstract

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were transplanted to low-density lipoprotein receptor-deficient mice. Atherosclerosis was induced by feeding the recipient mice a high-fat diet for 8 wk and evaluated using Oil Red O staining of the descending aorta at sacrifice. The molecular mechanisms triggering atherosclerosis was studied by examining splenic B and T cells, as well as Th1 and Th2 immune responses using flow cytometry and ELISA. The atherosclerotic lesion area in the descending aorta was ~5-fold larger in mice lacking FcgammaRIIB than in control mice (2.75 +/- 2.57 versus 0.44 +/- 0.42%; p < 0.01). Moreover, the FcgammaRIIB deficiency resulted in an amplified splenocyte proliferative response to Con A stimulation (proliferation index 30.26 +/- 8.81 versus 2.96 +/- 0.81%, p < 0.0001) and an enhanced expression of MHC class II on the B cells (6.65 +/- 0.64 versus 2.33 +/- 0.2...Continue Reading

References

Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·W PalinskiJ L Witztum
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·S AmeliJ Nilsson
Jun 1, 1997·The Journal of Clinical Investigation·S GuptaC Schindler
Sep 3, 1998·The Journal of Clinical Investigation·A NicolettiG K Hansson
Sep 17, 1998·The Journal of Clinical Investigation·S Y ParkT Saito
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T S LeeL Y Chau
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·L J Pinderski OslundA I Fyfe
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J W Knowles, N Maeda
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Jun 19, 2001·Immunology Letters·N R RatcliffeP M Morganelli
Aug 24, 2002·Circulation Research·Göran K HanssonZhong-Qun Yan
Sep 28, 2002·Current Opinion in Lipidology·Ziad Mallat, Alain Tedgui
Nov 2, 2002·Nature Medicine·Christoph J BinderJoseph L Witztum
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Gunilla Nordin FredriksonJan Nilsson
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Gunilla Nordin FredriksonJan Nilsson
May 22, 2004·Journal of Atherosclerosis and Thrombosis·Tamikazu NiwaMitsuru Seishima
Sep 14, 2004·Current Opinion in Lipidology·Jan Nilsson, Petri T Kovanen
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan NilssonPrediman K Shah
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chiara BuonoAndrew H Lichtman
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Sep 17, 2005·The Journal of Clinical Investigation·Adam M BoruchovJames W Young
Jan 18, 2006·Immunity·Falk Nimmerjahn, Jeffrey V Ravetch
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Oct 21, 2006·Circulation Research·Purificación Hernández-VargasCarmen Gómez-Guerrero
Feb 3, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Adi MorJacob George
Feb 20, 2007·International Immunology·Elahna PaulMichael C Carroll
Feb 27, 2007·Nature Immunology·Zou XiangKenneth G C Smith
Mar 17, 2007·Stroke; a Journal of Cerebral Circulation·Gunilla Nordin FredriksonJan Nilsson
Nov 28, 2007·Annual Review of Pathology·Göran K HanssonCecilia Söderberg-Nauclér
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracy L McGahaJeffrey V Ravetch
Apr 16, 2008·Journal of Internal Medicine·J Nilsson, G K Hansson
Jul 8, 2008·European Journal of Immunology·Mirentxu I IruretagoyenaAlexis M Kalergis
Oct 20, 2009·Cytokine·Jiang-jiao XieXiang Cheng

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Citations

Mar 17, 2012·Nature Reviews. Immunology·David J RawlingsAlmut Meyer-Bahlburg
Jan 3, 2013·The Journal of Clinical Investigation·Andrew H LichtmanJoseph L Witztum
Aug 14, 2013·Annual Review of Pathology·Joseph L Witztum, Andrew H Lichtman
Feb 23, 2017·Biochemical and Biophysical Research Communications·Yi ShiShen-Ming Wang
Dec 21, 2016·Journal of Cellular and Molecular Medicine·Jinyu SuMing Zhao
Jun 13, 2012·Experimental Biology and Medicine·Xinhong WangZuyi Yuan
Nov 26, 2011·Journal of Innate Immunity·Lorenza FrancescutCordula Stover
Nov 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaun W JacksonDavid J Rawlings
Jan 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jillian P RhoadsAmy S Major
Dec 18, 2014·Journal of the American Heart Association·Erin Y HarmonMichelle R Lennartz
Oct 29, 2011·Circulation Research·Christoph J Binder, Joseph L Witztum
Feb 20, 2016·Circulation Research·Daniel F J Ketelhuth, Göran K Hansson
Jan 17, 2015·Circulation Research·Keiji TanigakiPhilip W Shaul
May 17, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jayashree Bagchi-ChakrabortyAndrew P Sage
Aug 1, 2013·Physiological Reviews·Paul N Hopkins
Apr 24, 2020·Circulation Research·Jan Nilsson, Göran K Hansson
Feb 20, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aksam J MerchedMaria Sauvage-Merched
Dec 3, 2016·Current Transplantation Reports·Tomas Castro-Dopico, Menna R Clatworthy
Oct 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yunwei LouYun Zhang
Nov 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hang Pong NgShanmugam Nagarajan
Aug 28, 2021·Cardiovascular Research·Florentina PorschChristoph J Binder

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