FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis

Scandinavian Journal of Immunology
Maria AndrénS Kleinau

Abstract

IgG-binding Fc receptors, and in particular FcgammaRIII, are crucial for induction of collagen-induced arthritis (CIA), as FcgammaRIII-deficient mice are highly protected to arthritis. However, which of the FcgammaRIII-expressing cells that is responsible for induction of arthritis is not known. In this study, we have addressed this question by purifying different FcgammaRIII(+) cell populations, transferred them to FcgammaRIII-deficient mice and studied if the recipient mice can develop arthritis. The cell populations were isolated from spleen, bone marrow and the peritoneal cavity. Our results show that FcgammaRIII(+) CD11b(+) peritoneal macrophages can render FcgammaRIII-deficient mice susceptible to CIA. In contrast, FcgammaRIII(-) peritoneal macrophages or FcgammaRIII(+) spleenocytes, bone marrow cells, mast cells or monocytes could not mediate this effect. To further evaluate the contribution of the FcgammaRIII(+) macrophages in arthritis, we investigated the cytokine profile in these cells during CIA. The arthritic macrophages exhibited significantly higher mRNA levels of TNFalpha and IL-12p35 compared with macrophages from normal mice. We conclude that FcgammaRIII-expressing macrophages, producing pro-inflammatory cytok...Continue Reading

References

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Oct 2, 2002·European Journal of Immunology·Teresita Díaz de StåhlSandra Kleinau
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Citations

Oct 18, 2006·Springer Seminars in Immunopathology·Peter Boross, J Sjef Verbeek
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michaela SeelingFalk Nimmerjahn
May 25, 2007·Arthritis Research & Therapy·Sofia E MagnussonSandra Kleinau
May 23, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ernest BrahnColin Macaulay
May 2, 2008·Expert Opinion on Investigational Drugs·Malini BajpaiAbhijit Ray
Nov 30, 2010·Nature Chemical Biology·Julie A Di PaoloKevin S Currie

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