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FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

Nature Genetics

May 29, 2007

Manuela FanciulliTimothy J Aitman

Abstract

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic pol...read more

Mentioned in this Paper

FCGR3B protein, human
GPI-Linked Proteins
Gene Dosage
Leukocyte Differentiation Antigens, Human
Churg-Strauss Syndrome
Leu-11 Antigens
Autoimmune Diseases of the Nervous System
Malnutrition
FCGR3B wt Allele
Disease Susceptibility
195
Paper Details
References
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  • Citations270
12
  • References14
  • Citations270
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FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

Nature Genetics

May 29, 2007

Manuela FanciulliTimothy J Aitman

PMID: 17529978

DOI: 10.1038/ng2046

Abstract

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic pol...read more

Mentioned in this Paper

FCGR3B protein, human
GPI-Linked Proteins
Gene Dosage
Leukocyte Differentiation Antigens, Human
Churg-Strauss Syndrome
Leu-11 Antigens
Autoimmune Diseases of the Nervous System
Malnutrition
FCGR3B wt Allele
Disease Susceptibility
195

Feeds With Similar Papers

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Systemic Lupus Erythematosus

Systemic lupus erythematosus is an autoimmune disorder which can affect and damage any organ system in the body. It has a diverse range of immunological manifestations and is more prominent in young women, with the exact etiology still unknown. Here is the latest research on systemic lupus erythematosus.

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Paper Details
References
  • References14
  • Citations270
12
  • References14
  • Citations270
12345...

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