FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population

Lupus
Ji-Cheng LvH Zhang

Abstract

Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impact polygenic autoimmunity. FCGR3B CNV is associated with susceptibility to systemic autoimmunity in Caucasian populations. In this study, we examined FCGR3B CNV in patients with the autoimmune disease lupus nephritis (LN) in a Chinese population. The study includes 202 patients with histologically verified LN and 146 geographically matched healthy controls. To identify CNV at the FCGRB locus, quantitative polymerase chain reaction (PCR) was done with TaqMan( TM) probes and relative copy number was estimated with relative quantitative 2(-DeltaDeltaCt) method. The distribution of FCGR3B relative copy number did not differ significantly between the LN patients and the controls (1.17 +/- 0.42 for LN; 1.15 +/- 0.37 for controls; p = 0.627). The difference was still not significant when the data were stratified by gender. There was no significant difference when the LN patients were divided by pathological phenotype (proliferative LN compared with non-proliferative p = 0.511; AI < 12 compared with AI > or = 12, p = 0.401; and chronicity index (CI) < 4 compared with CI > or = 4, p = 0.058) or lupus disease activity index (SLEDAI < or = 1...Continue Reading

References

Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katleen De PreterJo Vandesompele
Aug 3, 2002·Nature Reviews. Immunology·Toshiyuki Takai
Jan 23, 2004·Genes and Immunity·V MagnussonUNKNOWN SLE Genetics Collaboration Group
Jan 13, 2006·BMC Genetics·Agnes SzilagyiZsolt Ronai
Jul 26, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas Schwarting
Sep 2, 2006·Arthritis and Rheumatism·Mumtaz PatelDeborah P M Symmons
Nov 24, 2006·Nature·Richard RedonMatthew E Hurles
Dec 26, 2006·Human Molecular Genetics·Scott J HebbringStephen N Thibodeau
Dec 7, 2007·Nature Genetics·Edward J HolloxJoost Schalkwijk
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch

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Citations

May 29, 2010·Human Molecular Genetics·Heather A NiedererKenneth G C Smith
Feb 18, 2012·Human Molecular Genetics·Cushla McKinney, Tony R Merriman
May 3, 2014·Journal of Human Genetics·Ohsuke MigitaKenichiro Hata
Jul 28, 2012·Human Mutation·Stuart Cantsilieris, Stefan J White
Jul 15, 2015·Briefings in Functional Genomics·Christina L Usher, Steven A McCarroll
Nov 7, 2017·Experimental and Therapeutic Medicine·Zhaohui ZhengZhangsuo Liu

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