FcγR2B B2.4 haplotype predicts increased risk of red blood cell alloimmunization in sickle cell disease patients.

Transfusion
Abel Costa NetoCarla Luana Dinardo

Abstract

Red blood cell (RBC) alloimmunization is an important transfusion complication which is prevalent among sickle cell disease (SCD) patients. Autoimmune diseases are a known risk factor for RBC alloimmunization, suggesting that autoimmunity and post-transfusion alloantibody development occur through similar physiopathological pathways. Polymorphisms in the FcγR2B gene have already been associated with several autoimmune disorders and hypothetically could be associated with RBC alloimmunization. Our goal was to evaluate if important polymorphisms of FcγR2B have an impact on the risk of RBC alloimmunization among SCD patients. This was a case-control study in which alloimmunized and non-alloimmunized SCD patients were compared in terms of the genotype frequency of the FcγR2B polymorphisms -386G/C, -120 T/A, and 695C/T, genotyped through direct Sanger sequencing. A total of 237 patients met the eligibility criteria, 120 cases (alloimmunized) and 117 controls (non-alloimmunized). RBC alloimmunization was associated with female sex (p < 0.001), lifetime number of RBC units transfused (p = 0.002) and 120 T/A FcγR2B genotype (p = 0.031). The FcγR2B promoter region haplotype 2B.4 (386C120A) was positively associated with RBC alloimunizat...Continue Reading

References

Jun 7, 1990·The New England Journal of Medicine·E P VichinskyB Lubin
Feb 24, 2001·Seminars in Hematology·E P Vichinsky
Aug 23, 2006·The Journal of Experimental Medicine·Meggan MackayBetty Diamond
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
May 9, 2012·The American Journal of Medicine·Pavol PapayGünther F Körmöczi
Jul 19, 2012·Transfusion·Scott T MillerUNKNOWN Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN)
Jan 31, 2014·Revista brasileira de hematologia e hemoterapia·Carla Luana DinardoAlfredo Mendrone Júnior
Feb 12, 2015·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Neil A HanchardAlice Chen
Oct 13, 2015·British Journal of Haematology·Alex B RyderChristopher A Tormey
Oct 27, 2015·Immunological Reviews·Chantal E HargreavesJonathan C Strefford
Dec 20, 2015·Immunological Reviews·Marion EspéliMenna R Clatworthy
Dec 4, 2016·Hematology·Jeanne E Hendrickson, Christopher A Tormey
Dec 4, 2016·Hematology·Karina Yazdanbakhsh
Jul 22, 2018·British Journal of Haematology·Anna B F Carneiro-ProiettiUNKNOWN International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.