FcγRI-coupled signaling in peripheral nociceptors mediates joint pain in a rat model of rheumatoid arthritis

Arthritis & Rheumatology
Fan LiuChao Ma

Abstract

Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies demonstrated that functional FcγRI was expressed in dorsal root ganglion neurons, and might contribute to pain in rodent models of antigen-induced arthritis (AIA). This study was performed to elucidate the roles of nociceptive neuronal FcγRI-coupled signaling in the development of joint pain in AIA. RNA sequencing was used to investigate the transcriptome profile changes in the dorsal root ganglion (DRG) in a rat model of AIA. A primary sensory neuron-specific Fcgr1a conditional knockout (CKO) rat was established by crossing rats carrying a loxP-flanked Fcgr1a with a Pirt-specific Cre line. Behavioral, morphological and molecular studies were conducted to evaluate the differences between wild-type and CKO rats after AIA. We first showed that AIA induced a transcriptome profile change in the DRG, involving a number of key proteins downstream of the FcγRI-related signaling pathway. Compared to the wild-type rats, both the IgG-immune complex-induced acute pain and AIA-induced pain were alleviated in CKO rats. Moreover, the AIA-induced activation of FcγRI-related signaling in DRGs was significantly reduced in CKO rats. In addition, CKO r...Continue Reading

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Citations

Apr 2, 2021·Acta Biochimica Et Biophysica Sinica·Chunyan LiYingjie Wei
May 14, 2021·Pain Reports·Michael J LacagninaPeter M Grace

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