FDA approved drugs as potential Ebola treatments

F1000Research
Sean Ekins, Megan Coffee

Abstract

In the search for treatments for the Ebola Virus, multiple screens of FDA drugs have led to the identification of several with promising in vitro activity. These compounds were not originally developed as antivirals and some have been further tested in mouse in vivo models. We put forward the opinion that some of these drugs could be evaluated further and move into the clinic as they are already FDA approved and in many cases readily available. This may be important if there is a further outbreak in future and no other therapeutic is available.

References

Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Feb 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christopher T Walsh, Michael A Fischbach
Jun 10, 2009·Antimicrobial Agents and Chemotherapy·Els KeyaertsPiet Maes
Mar 8, 2011·Drug Discovery Today·Sean EkinsJoel S Freundlich
Jun 22, 2011·Briefings in Bioinformatics·Joel T DudleyAtul J Butte
Aug 19, 2011·Science Translational Medicine·Joel T DudleyAtul J Butte
Jul 25, 2012·The AAPS Journal·T I Oprea, J Mestres
Jun 21, 2013·Science Translational Medicine·Lisa M JohansenGene G Olinger
Apr 1, 2014·Antiviral Research·Siwaporn BoonyasuppayakornRadhakrishnan Padmanabhan
Apr 9, 2014·The Journal of Antimicrobial Chemotherapy·Gerrit GehringThomas von Hahn
May 21, 2014·Antimicrobial Agents and Chemotherapy·Julie DyallMatthew B Frieman
Aug 26, 2014·Drug Discovery Today·Julie BlattWilliam P Janzen
Sep 15, 2014·The Lancet Infectious Diseases·Mohamad-Ali TradPaul Anantharajah Tambyah
Sep 16, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Zhongqi DongJames E Polli
Oct 17, 2014·Nature·Declan Butler, Lauren Morello
Feb 26, 2015·F1000Research·Nadia LittermanSean Ekins
Jun 4, 2015·Emerging Microbes & Infections·Jennifer KouznetsovaAdolfo García-Sastre

❮ Previous
Next ❯

Citations

Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Sean EkinsPeter B Madrid
Jun 13, 2020·F1000Research·Shawn GoyalDonald R Branch
May 8, 2015·F1000Research·Sean EkinsMegan Coffee
Feb 8, 2019·ACS Omega·Manu AnantpadmaSean Ekins
Dec 6, 2018·ACS Infectious Diseases·Elena K Schneider-FutschikTony Velkov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Survival News : the Monthly Publication of AIDS Survival Project
Gerry Hoyt
BMJ : British Medical Journal
D Bennett, D Brown
Relevé épidémiologique Hebdomadaire
© 2021 Meta ULC. All rights reserved