FDG and FLT-PET for Early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Kevin P HornJohn M Hoffman

Abstract

Metastatic renal cell carcinoma has a poor prognosis and an intrinsic resistance to standard treatment. Sunitinib is an oral receptor tyrosine kinase inhibitor that has been used as a first-line targeted therapy in metastatic renal cell carcinoma. While computed tomography (CT) is currently the gold standard for response assessment in oncological trials, numerous studies have shown that positron emission tomography (PET) imaging can provide information predictive of tumor response to treatment earlier than the typical interval for standard of care follow-up CT imaging. In this exploratory study we sought to characterize early tumor response in patients with metastatic renal cell carcinoma treated with continuous daily 37.5 mg sunitinib therapy. Twenty patients underwent dynamic acquisition positron emission tomography (PET) imaging using (18) F-fluorodeoxyglucose (FDG) and (18) F-fluorothymidine (FLT) at baseline and early in treatment (after 1, 2, 3 or 4 weeks) with 37.5 mg continuous daily dosing of sunitinib. Semi-quantitative analyses were performed to characterize the tumor metabolic (FDG) and proliferative (FLT) responses to treatment. Proliferative responses were observed in 9/19 patients and occurred in 2 patients at on...Continue Reading

References

Nov 11, 1998·Nature Medicine·A F ShieldsT J Mangner
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideDenis Agostini
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navneet S MajhailRonald M Bukowski
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fortunato CiardielloGiampaolo Tortora
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gary J KelloffDaniel C Sullivan
Jul 2, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Anthony F ShieldsOtto Muzik
Nov 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Rakesh KumarAbass Alavi
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandrine FaivreEric Raymond
Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerBrian I Rini
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Robert J MotzerM Dror Michaelson
Nov 23, 2006·Clinical Nuclear Medicine·Nathan LawrentschukA M Scott
Jun 11, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexander M SpenceKenneth A Krohn
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John O PriorSerge Leyvraz
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 27, 2009·Cancer Biotherapy & Radiopharmaceuticals·Laetitia VercellinoJean-Luc Moretti
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerRobert A Figlin
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joshua S ScheuermannBarry A Siegel
Dec 8, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·M E RevheimW Lilleby
Jul 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irfan KayaniThomas Powles
Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Glenn LiuGeorge Wilding
Aug 21, 2012·Current Opinion in Pharmacology·Giampaolo Tomasi, Lula Rosso
May 16, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Omid S Tehrani, Anthony F Shields
Apr 25, 2014·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Bal SangheraKirit Ardeshna

❮ Previous
Next ❯

Citations

Oct 23, 2016·Abdominal Radiology·Masatoyo NakajoTakashi Yoshiura
Jun 8, 2017·The British Journal of Radiology·Massimo GaliaRoberto Lagalla
Feb 13, 2019·Current Opinion in Oncology·Liza LindenbergKirsten Bouchelouche
May 20, 2016·Abdominal Radiology·Reza SirousAndrew D Smith
Aug 31, 2019·Current Urology Reports·Vidhya KariveduAbhinav Sidana
Jun 5, 2016·Current Opinion in Urology·Katherine M Krajewski, Atul B Shinagare
Oct 18, 2016·Clinical Nuclear Medicine·Sebastien DejustDimitri Papathanassiou
Jan 8, 2019·The Journal of Clinical Investigation·John C ChappellW Kimryn Rathmell
Apr 25, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Oke GerkeWerner Vach
Mar 3, 2020·Frontiers in Oncology·David M VailRobert Jeraj
May 26, 2016·Japanese Journal of Radiology·Kazuhiro KitajimaHossein Jadvar
Jun 10, 2021·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Rahul JenaAneesh Srivastava

❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy test
surgical resection

Clinical Trials Mentioned

NCT00694096

Software Mentioned

R development
R

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.