FDG-PET and MRI in temporal lobe epilepsy: relationship to febrile seizures, hippocampal sclerosis and outcome

Acta Neurologica Scandinavica
V SalanovaB Azzarelli

Abstract

To correlate the volumetric head magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET) scan findings with the history, intracarotid amobarbital procedure, pathology, and outcome in patients with medically refractory temporal lobe epilepsy. Thirty-eight patients with temporal lobe epilepsy treated surgically following a comprehensive presurgical evaluation. Follow-up ranged from 12 to 44 months. Volumetric MRI showed ipsilateral hippocampal atrophy in 29 (76%), and PET scan showed ipsilateral temporal hypometabolism (PET-TH) in 31 (81.5%) of patients. Eighty-three percent of those patients with hippocampal sclerosis on MRI (MRI-HS) had ipsilateral PET-TH. Sixty-six percent of patients with MRI-HS had a history of prolonged febrile convulsions or a childhood febrile illness accompanied by convulsions, and 77% of patients with MRI-HS had pathologically proven hippocampal sclerosis (HS). Ninety percent became seizure free or had rare seizures. FDG-PET scans and head MRIs were complementary; 95% of patients had either MRI-HS or temporal hypometabolism. MRI-HS correlated with a history of febrile seizures and pathologically demonstrated hippocampal sclerosis. Ninety-three percent of patients h...Continue Reading

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Citations

Jul 20, 2007·Human Brain Mapping·Tejas SankarAndrea Bernasconi
Jul 18, 2008·European Journal of Pediatrics·Andreas MerkenschlagerMatthias K Bernhard
Apr 19, 2018·Neurosurgery·D Ryan OrmondAlexander Grote
Sep 6, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B SzeliesW D Heiss
Jul 30, 2004·Brain : a Journal of Neurology·R P CarneM J Cook
May 4, 2011·British Journal of Hospital Medicine·Simon W DubreyWojtek P Rakowicz
Jan 7, 2004·Acta Neurologica Scandinavica·V SalanovaR Worth
Nov 4, 2008·Nature Clinical Practice. Neurology·Manoj Chungath, Simon Shorvon
Oct 30, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zeenat JaisaniArie L Weinstock
Mar 8, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Manish N ShahMatthew D Smyth
Mar 19, 2011·European Journal of Pediatrics·Iren OroszJürgen Sperner
Jan 13, 2005·Acta Neurologica Scandinavica·V SalanovaR Worth

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