FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes

Brain : a Journal of Neurology
S Younes-MhenniJ Honnorat

Abstract

To determine the usefulness of [18F]fluorodeoxyglucose (FDG) whole body FDG-PET in the diagnosis of tumours in patients with paraneoplastic neurological syndromes (PNS), we prospectively studied 20 patients with paraneoplastic antibodies in whom conventional imaging gave negative or inconclusive results for the presence of tumour. All 20 patients had neurological manifestations compatible with PNS and well-characterized paraneoplastic antibodies (12 anti-Hu, one anti-Hu and anti-CV2, one anti-CV2, four anti-Yo, one anti-Ri and one anti-amphiphysin). The mean delay between the onset of neurological symptoms and FDG-PET was 10 months (range 1-54). In these 20 patients, abnormal uptake was demonstrated in 18 patients, with some patients having abnormal signal in several areas. We observed abnormal uptake in the mediastinum (13 cases), lung (two cases), breast (two cases), parotid gland (one case), or the cervical, supraclavicular or axillary lymph nodes (seven cases). Following FDG-PET, the histological diagnosis of the tumour was made in 14 patients (small cell lung carcinoma in eight cases, breast adenocarcinoma in two, lung adenocarcinoma in two, axillary metastasis of ovary carcinoma in one, and malignant thymoma in one). Two ...Continue Reading

Citations

May 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kayihan UlucOnder Us
Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hitoshi MurakamiToshio Imada
Aug 30, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Steven Vernino
Nov 30, 2005·Journal of Neuro-oncology·T LeyheT Haarmeier
Feb 26, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sandip Basu, Abass Alavi
Apr 26, 2006·Current Neurology and Neuroscience Reports·Steven Vernino
Dec 17, 2010·Current Neurology and Neuroscience Reports·Elizabeth M Wells, Josep Dalmau
Feb 14, 2006·Current Neurology and Neuroscience Reports·Myrna R Rosenfeld, Josep Dalmau
Dec 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·María José Molina-GarridoMaría Guirado-Risueño
Sep 23, 2006·Nature Clinical Practice. Neurology·James CastleDavid E Newman-Toker
Feb 8, 2006·Nature Clinical Practice. Oncology·Antonio Santillan, Robert E Bristow
May 15, 2007·The Neurologist·Steven VerninoBradley Boeve
Mar 14, 2009·The Neurologist·Vicente VillanuevaEloy Elices
Jul 22, 2009·Current Opinion in Oncology·Adrien Didelot, Jérôme Honnorat
Aug 24, 2013·Journal of Clinical Neuromuscular Disease·Yousef HannawiYogeshwar V Kalkonde
Jun 7, 2012·Nuclear Medicine Communications·Sriram VaidyanathanSai Han
Jan 10, 2009·The Neurologist·Thomas B Toothaker, Michael Rubin
Mar 19, 2008·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Melissa W KoSteven L Galetta
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C A VedelerUNKNOWN Paraneoplastic Neurological Syndrome Euronetwork
Oct 1, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M J TitulaerUNKNOWN European Federation of Neurological Societies
Mar 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R ScheidD Y von Cramon
Nov 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·J Honnorat
Apr 23, 2008·International Seminars in Surgical Oncology : ISSO·Alia NooraniKefah Mokbel
May 8, 2007·Orphanet Journal of Rare Diseases·Jérôme Honnorat, Jean-Christophe Antoine
May 19, 2010·The Oncologist·Myrna R Rosenfeld, Josep Dalmau
Oct 30, 2013·Case Reports in Neurological Medicine·Linda HasadsriMingtao Wang
Jul 13, 2013·Practical Neurology·Sidra AurangzebMartin R Turner
Jan 29, 2011·Neuroradiology·Philippe DemaerelJennifer Linn
Sep 23, 2014·Current Problems in Cancer·Samuel MartelGiovanna Speranza
Mar 25, 2005·Journal of Neurology·R ScheidD Y von Cramon
Oct 14, 2008·Revue neurologique·J-C Antoine, UNKNOWN PNS Euronet group
Mar 14, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anette Storstein, Christian A Vedeler
May 14, 2005·Current Opinion in Neurology·Edward J Dropcho
Sep 13, 2005·Current Opinion in Neurology·Stacy A Rudnicki, Josep Dalmau
Jan 12, 2007·Current Opinion in Neurology·Agnes Wong
Oct 12, 2010·Expert Review of Neurotherapeutics·Franz Blaes, Marlene Tschernatsch
Mar 29, 2014·Expert Review of Clinical Immunology·Chrissa SiokaAthanassios P Kyritsis
Oct 7, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Philippe CorciaJean-Philippe Camdessanche
May 13, 2010·The American Journal of the Medical Sciences·Tareq BraikSusan McDunn
Feb 13, 2015·Rinshō shinkeigaku = Clinical neurology·Soutarou TaguchiAkira Takahashi
Aug 24, 2013·Survey of Ophthalmology·Ehsan Rahimy, David Sarraf

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