FDG-PET in healthy and epileptic Lagotto Romagnolo dogs and changes in brain glucose uptake with age

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Tarja S JokinenLiisa Metsähonkala

Abstract

Regional cerebral metabolism and blood flow can be measured noninvasively with positron emission tomography (PET). 2-[(18) F]fluoro-2-deoxy-D-glucose (FDG) widely serves as a PET tracer in human patients with epilepsy to identify the seizure focus. The goal of this prospective study was to determine whether juvenile or adult dogs with focal-onset epilepsy exhibit abnormal cerebral glucose uptake interictally and whether glucose uptake changes with age. We used FDG-PET to examine six Lagotto Romagnolo dogs with juvenile epilepsy, two dogs with adult-onset epilepsy, and five control dogs of the same breed at different ages. Three researchers unaware of dog clinical status visually analyzed co-registered PET and magnetic resonance imaging (MRI) images. Results of the visual PET analyses were compared with electroencephalography (EEG) results. In semiquantitative analysis, relative standard uptake values (SUV) of regions of interest (ROI) drawn to different brain regions were compared between epileptic and control dogs. Visual analysis revealed areas of hypometabolism interictally in five out of six dogs with juvenile epilepsy in the occipital, temporal, and parietal cortex. Changes in EEG occurred in three of these dogs in the sam...Continue Reading

References

May 1, 1991·Epilepsia·D B LeidermanW H Theodore
Jan 1, 1988·Epilepsia·W H Theodore
Jan 1, 1983·Neurobiology of Aging·E D LondonS I Rapoport
Jan 1, 1994·European Neurology·H G Wieser
Dec 19, 2001·Journal of Korean Medical Science·D S LeeM C Lee
Feb 28, 2002·Psychiatry Research·Mark W WillisRobert M Post
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathelijne PeremansRudi Dierckx
Jun 6, 2003·The Veterinary Journal·L BergamascoA Jaggy
Oct 11, 2003·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Rey CasseAndrew M Scott
Oct 19, 2004·Lancet Neurology·Christian E ElgerMartin Kurthen
May 6, 2005·Brain : a Journal of Neurology·Eun Yeon JooByung Tae Kim
Mar 23, 2006·Journal of Child Neurology·Krisztina BenedekHarry T Chugani
Mar 24, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Elizabeth A BallegeerR Jerome Nickles
Feb 16, 2007·Physics in Medicine and Biology·Hugo W A M de JongAdriaan A Lammertsma
Jun 8, 2007·Journal of Veterinary Internal Medicine·T S JokinenS Cizinauskas
Apr 19, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeBancGregory B Daniel
Jun 3, 2008·Seminars in Nuclear Medicine·Karolien GoffinWim Van Paesschen
Dec 5, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Ki-Dong EomHee-Myung Park
Apr 30, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeBlancGregory B Daniel
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneUNKNOWN European Association of Nuclear Medicine Neuroimaging Committee
Nov 4, 2009·Annals of Internal Medicine·Aaron L NelsonDavid M Kent
Nov 7, 2009·Clinical Nuclear Medicine·Roland TalanowGuiyun Wu
Nov 26, 2009·Pediatric Radiology·Sunhee KimAshok Panigrahy
Dec 17, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Valentine MartléLuc Van Ham
Dec 17, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Jessica LawrenceDavid M Vail
Dec 17, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Min-Su LeeKi-Dong Eom
Mar 11, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Anders E HansenAnnemarie T Kristensen
Aug 11, 2011·PLoS Genetics·Eija H SeppäläHannes Lohi
Nov 29, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anders E HansenSvend A Engelholm
Mar 1, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeblancFederica Morandi

❮ Previous
Next ❯

Citations

Jun 3, 2015·Journal of Veterinary Internal Medicine·A PakozdyD Hasegawa
Feb 28, 2017·American Journal of Veterinary Research·Shunta MizoguchiMichio Fujita
Mar 28, 2018·American Journal of Veterinary Research·Antje HartmannMartin J Schmidt
Jan 13, 2018·Frontiers in Veterinary Science·Marion Bankstahl, Jens P Bankstahl
May 20, 2020·BMC Veterinary Research·Antje HartmannInes E Lautenschläger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.