FDG-PET Scanning Shows Distributed Changes in Cortical Activity Associated with Visual Hallucinations in Eye Disease

Endocrine, Metabolic & Immune Disorders Drug Targets
Lütfü HanogluBurak Yulug

Abstract

Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired patients is still not clear. In our study, we have scanned three patients with eye disease and CBS (VH+) and three patients with eye disease without CBS (VH-) using FDG-PET. Our results showed underactivity in the pons and overactivity in primary right left visual cortex and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18FFDG PET data that was taken from the database consisting of 50 age-matched healthy adults without neuropsychiatric disorders. From this distributed pattern of activity changes, we conclude that the generation of visual hallucination in CBS is associated with bottom-up and top-down mechanism rather than the generally accepted visual deafferentation-related hyperexcitability theory.

References

Dec 1, 1992·The American Journal of Psychiatry·S HolroydS C Wisniewski
Feb 1, 1989·Fortschritte der Neurologie-Psychiatrie·K PodollJ Noth
Aug 23, 1973·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·D G Cogan
Feb 1, 2003·Survey of Ophthalmology·G Jayakrishna MenonGordon N Dutton
Jun 24, 2008·BMC Neurology·Spiridon PapapetropoulosBonnie Levin
Jul 1, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Dominic H Ffytche
Jul 17, 2009·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Hiroaki KazuiMasatoshi Takeda
Aug 5, 2010·International Journal of Geriatric Psychiatry·G GrahamD Collerton
Dec 11, 2013·Clinical Nuclear Medicine·Ümit Özgür AkdemirLütfiye Özlem Kapucu
Feb 15, 2014·Progress in Neurobiology·James M ShineSimon J G Lewis
Jan 25, 2017·International Journal of Geriatric Psychiatry·Gregor RussellAlistair Burns

❮ Previous
Next ❯

Citations

Feb 11, 2020·Current Opinion in Psychiatry·Theresa M MarschallIris E C Sommer
Sep 9, 2020·Current Opinion in Ophthalmology·Katherine A Coerver, Prem S Subramanian
Oct 4, 2020·Current Opinion in Ophthalmology·Katherine A Coerver, Prem S Subramanian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.