FDG-PET staging and importance of lymph node SUV in head and neck cancer.

Head & Neck Oncology
Gregory J KubicekMitchell Machtay

Abstract

The role of positron emission tomography (PET) with fluoro-deoxy-glucose (FDG) in the staging of head and neck cancer (HNC) is unclear. The NCCN guidelines do not recommend FDG-PET as a part of standard workup. The purpose of this report is to examine the role of FDG-PET imaging in altering management and providing prognostic information for HNC. Retrospective review of HNC patients who had a staging FDG-PET scan performed at either Thomas Jefferson University or University of Kansas Medical Center between the years 2001 and 2007. A total of 212 PET scans were performed in patients who went on to receive radiotherapy. The median follow-up time for all patients was 469 days. The PPV and NPV of PET imaging to correctly identify lymph node status was 94% and 89% respectively. Lymph nodes with extracapsular extension (ECE) had higher SUVs than nodes without ECE, 11.0 vs. 5.0 (p < 0.0007). Maximum SUV for the primary tumor > 8.0 was predictive of worse overall survival (p < 0.045), while the SUV of the lymph nodes was predictive for distant recurrence at one year--with a mean SUV value of 10.4 for patients with distant failure vs. 7.0 without (p < 0.05). FDG-PET staging in head and neck cancer has good positive and negative predicti...Continue Reading

References

Mar 1, 2002·British Journal of Cancer·W HalfpennyM McGurk
Mar 3, 2004·Radiology·Heiko SchöderSteven M Larson
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Abdelkarim S AllalPavel Dulguerov
Dec 22, 2004·Archives of Otolaryngology--head & Neck Surgery·David L SchwartzKenneth Krohn
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·David L SchwartzGeorge E Laramore
Apr 29, 2005·Radiology·Barton F BranstetterCarolyn C Meltzer
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Aug 29, 2006·International Journal of Clinical Oncology·Keigo EndoKeiko Koyama
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shu-Hang NgChun-Ta Liao
Feb 20, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-L RohS Y Kim
Feb 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Ryuji MurakamiYasuyuki Yamashita
Mar 1, 2007·Nature Clinical Practice. Oncology·Tanguy Y SeiwertEverett E Vokes
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sang Yoon KimSung-Bae Kim
Oct 26, 2007·The New England Journal of Medicine·Jan B VermorkenUNKNOWN EORTC 24971/TAX 323 Study Group
Oct 26, 2007·The New England Journal of Medicine·Marshall R PosnerUNKNOWN TAX 324 Study Group
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell MachtayK Kian Ang
May 2, 2009·European Journal of Radiology·T D PoeppelG Antoch
Jan 29, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Chun-Ta LiaoTzu-Chen Yen

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Next ❯

Citations

Aug 31, 2013·European Journal of Nuclear Medicine and Molecular Imaging·M PicchioI Castiglioni
Sep 1, 2011·Otolaryngologia polska. The Polish otolaryngology·Magdalena KuźmińskaKazimierz Niemczyk
May 14, 2014·PloS One·Kazuhiro KitajimaKazuro Sugimura
Jan 21, 2014·Journal of Neuro-oncology·Colin E ChampWenyin Shi
Mar 14, 2013·Imaging in Medicine·Vasavi PaidpallyRathan M Subramaniam
Feb 25, 2014·Journal of Radiation Oncology·Adam A GarsaWade L Thorstad
Mar 1, 2016·Cancer Treatment Reviews·Bishal GyawaliYuichi Ando
Mar 25, 2014·Oral and Maxillofacial Surgery Clinics of North America·Jonathan W Shum, Eric J Dierks
Jan 20, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Gianpiero MancaDuccio Volterrani
Jul 31, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·May TeohCatharine H Clark
May 18, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·R J D PrestwichA F Scarsbrook
Mar 23, 2012·Oral Oncology·Vikas Mehta, Robert L Ferris
Jun 5, 2013·Australian Dental Journal·C S FarahB W Lee
Jun 19, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Azeem S KakaTheodoros N Teknos
Aug 4, 2015·Medical Physics·Heyse LiJean-Pierre Bissonnette
Mar 26, 2013·Oral Oncology·Wouter L LodderFrank A Pameijer
Feb 25, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Federico Bozzetti, Beth Zupec-Kania
Dec 16, 2011·International Journal of Radiation Oncology, Biology, Physics·Min YaoMitchell Machtay
Dec 11, 2014·World Journal of Clinical Oncology·Peter GeorgesGregory J Kubicek
Oct 19, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Suat KılıçRichard Chan Woo Park
Feb 27, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Samer Ahmed IbrahimIslam Mohammed Hussein Darahem
Oct 29, 2015·Japanese Journal of Radiology·Kazuhiro KitajimaKazuro Sugimura
Jun 3, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·W-K YapT-M Hung
May 26, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J CacicedoD Rades

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Methods Mentioned

BETA
biopsies
dissection
dissections
biopsy

Software Mentioned

GraphPad
OSEM

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