FDG PET/CT in Acute Tumefactive Multiple Sclerosis Occurring in a Case of Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Clinical Nuclear Medicine
Aisheng DongChangjing Zuo

Abstract

Tumefactive multiple sclerosis refers to the presentation of large demyelinating lesions (≥2 cm in diameter) mimicking brain tumors clinically and radiologically. We present the MRI and FDG PET/CT findings in a case with tumefactive multiple sclerosis, who had chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Head MRI showed 7 cerebral lesions with incomplete ring enhancement. All but one lesion had size more than 2 cm. All these demyelinating lesions showed increased uptake at the rims of the lesions with central hypometabolism. Stereotactic brain biopsy of the right frontal lesion revealed extensive macrophage and lymphocyte infiltration.

References

Feb 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·C SchiepersH Carton
Mar 8, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M V PadmaJ Mantil
Jun 7, 2008·Brain : a Journal of Neurology·C F LucchinettiW Brück
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Sep 26, 2009·Seminars in Immunopathology·Wei Hu, Claudia F Lucchinetti
Jan 3, 2013·Acta Neurologica Scandinavica·M NagappaS K Shankar
Apr 2, 2014·Clinical Nuclear Medicine·Anna Margherita MaffioneDomenico Rubello

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