FDG-PET/CT to predict optimal primary cytoreductive surgery in patients with advanced ovarian cancer: preliminary results

Tumori
Alessandra AlessiFlavio Crippa

Abstract

Primary cytoreductive surgery (CRS) has a significant impact on prognosis in epithelial ovarian cancer (EOC). Patient selection is important to recognize factors limiting optimal CRS and to avoid unnecessary aggressive surgical procedures. We evaluated the contribution of fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in the presurgical identification of disease sites that may preclude EOC cytoreducibility. Patients with suspected EOC underwent 18F-FDG-PET/CT within 20 days before debulking surgery. The PET/CT results were compared with surgical findings and postsurgery histopathology in order to assess the diagnostic value. Between August 2013 and January 2014, 29 patients were evaluated. The histopathology showed 23 EOC and 6 benign tumors. The FDG-PET/CT was positive (maximum standardized uptake value [SUVmax] 11.3 ± 5.4) in 21/23 (91%) patients with EOC and provided 2 false-negatives (1 mucinous and 1 clear cell carcinoma; SUVmax ≤2.8). The FDG-PET/CT was true-negative (SUVmax 2.2 ± 1.6) in 4 out of 6 patients (67%). False-positive FDG-PET results were obtained in 2 cellular fibromas (SUVmax 4.8 and 5.6). The sensitivity, specificity, and accuracy of PET/CT to characterize ovarian masse...Continue Reading

References

Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E BristowF J Montz
Jun 2, 2006·Obstetrics and Gynecology·Snehal Bhoola, William J Hoskins
Jan 19, 2007·Gynecologic Oncology·Signe RisumSvend A Engelholm
Dec 18, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Christophe PomelKarina Reynolds
Apr 22, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yorito YamamotoTakao Fukaya
Mar 17, 2011·Nuclear Medicine Communications·Kazuhiro KitajimaKazuro Sugimura
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ignace VergoteAntonio Casado
Dec 14, 2011·Clinical Nuclear Medicine·Dimitrios KarantanisJohannes Czernin
Apr 10, 2012·Gynecologic Oncology·Jason E DodgeUNKNOWN Gynecology Cancer Disease Site Group
Jan 16, 2013·Acta Radiologica·Ashraf Anas ZytoonMahmoud El-Gammal
Sep 10, 2013·Radiologic Clinics of North America·Jacqueline Brunetti
Jan 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yuko TanizakiKazuhiko Ino

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Citations

Sep 1, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Weining WangMelissa Ching Ching Teo
Jul 10, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jamie MarkoDarcy J Wolfman
Aug 24, 2017·The British Journal of Radiology·Priya Narayanan, Anju Sahdev
Feb 11, 2021·Cancers·Ami PatelNicole D Fleming
Jun 5, 2021·PloS One·Kira Philipsen PrahmEstrid Høgdall

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