FE65 in Alzheimer's disease: neuronal distribution and association with neurofibrillary tangles

The American Journal of Pathology
B DelatourC Duyckaerts

Abstract

FE65, a protein expressed in the nervous system, has the ability to bind the C-terminal domain of the amyloid precursor protein. This suggests a role for FE65 in the pathogenesis of Alzheimer's disease (AD). The present study was conducted to find out if the distribution of FE65 immunoreactivity was affected during the course of AD, and to determine the degree of co-localization of FE65 with other proteins known to be involved in AD. Single immunoperoxidase-labeling experiments, conducted on six sporadic AD patients and six nondemented age-matched controls, showed that the proportion of volume occupied by FE65 immunoreactivity was not modified in the isocortex of AD patients. However, in hippocampal area CA4, increased FE65 immunoreactivity seemed to be associated with the severity of the disease. Double-immunofluorescent labeling did not show any clear co-localization of FE65 with the amyloid precursor protein. FE65 immunoreactivity was also absent from focal and diffuse deposits of the beta-amyloid peptide. Unexpectedly double labeling experiments showed a co-localization of FE65 and tau proteins in intracellular tangles. Ultrastructural observations confirmed that FE65 was associated with paired helical filaments.

Citations

Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Nov 19, 2002·Neuroscience·S KesavapanyD M McLoughlin
Jan 24, 2007·Journal of Neurochemistry·Bor Luen Tang, Yih Cherng Liou
May 20, 2008·Journal of Neurochemistry·Ye He, Patrizia Casaccia-Bonnefil
Sep 26, 2003·Neuropathology and Applied Neurobiology·N GirardotC Duyckaerts
Nov 15, 2006·The European Journal of Neuroscience·X MecklerA Hémar
Mar 31, 2015·Journal of Alzheimer's Disease : JAD·Danton H O'DayMichael A Myre
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·Pengcheng Han, Jiong Shi
Feb 3, 2005·Neurobiology of Disease·Christian BarbatoPietro Calissano

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