Fear and Reward Circuit Alterations in Pediatric CRPS

Frontiers in Human Neuroscience
L E SimonsD Borsook

Abstract

In chronic pain, a number of brain regions involved in emotion (e.g., amygdala, hippocampus, nucleus accumbens, insula, anterior cingulate, and prefrontal cortex) show significant functional and morphometric changes. One phenotypic manifestation of these changes is pain-related fear (PRF). PRF is associated with profoundly altered behavioral adaptations to chronic pain. For example, patients with a neuropathic pain condition known as complex regional pain syndrome (CRPS) often avoid use of and may even neglect the affected body area(s), thus maintaining and likely enhancing PRF. These changes form part of an overall maladaptation to chronic pain. To examine fear-related brain circuit alterations in humans, 20 pediatric patients with CRPS and 20 sex- and age-matched healthy controls underwent functional magnetic resonance imaging (fMRI) in response to a well-established fearful faces paradigm. Despite no significant differences on self-reported emotional valence and arousal between the two groups, CRPS patients displayed a diminished response to fearful faces in regions associated with emotional processing compared to healthy controls. Additionally, increased PRF levels were associated with decreased activity in a number of brai...Continue Reading

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Citations

Aug 11, 2016·Frontiers in Human Neuroscience·Michael L MeierSabina Hotz-Boendermaker
Aug 1, 2019·Clinical Child Psychology and Psychiatry·Peter M McInnisKasia Kozlowska
Nov 26, 2019·Pain·Lauren C HeathcoteLaura E Simons
May 31, 2018·Journal of Pediatric Psychology·Christina M Low KapaluDustin P Wallace
Oct 18, 2019·Neuroscience and Biobehavioral Reviews·Inge TimmersLaura E Simons
Oct 17, 2020·The Lancet Child & Adolescent Health·Christopher EcclestonChantal Wood

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Linear Image Registration Tool
GLM FEAT
FMRIB Software Library ( FSL
FEAT
Linear Motion Correction ( MCFLIRT )
FSL Featquery
BET
FMRIB
FSL
MacStim

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