Fear memories induce a switch in stimulus response and signaling mechanisms for long-term potentiation in the lateral amygdala

The European Journal of Neuroscience
Bradley W Schroeder, Patricia Shinnick-Gallagher

Abstract

Activity-dependent modification of synapses is fundamental for information storage in the brain and underlies behavioral learning. Fear conditioning is a model of emotional memory and anxiety that is expressed as an enduring increase in synaptic strength in the lateral amygdala (LA). Here we analysed synaptic plasticity in the rat cortico-LA pathway during maintenance of fear memory. We show for the first time that the stimulus frequency for synaptic potentiation is switched during maintenance of fear memory, and the underlying signaling mechanisms are altered in the cortico-LA pathway. In slices from fear-conditioned animals, high-frequency stimulation-induced (HFS) long-term potentiation (LTP) was attenuated, whereas low-frequency stimulation (LFS) elicited a long-lasting potentiation. HFS generates robust LTP that is dependent on N-methyl-d-aspartate receptor (NMDAR) and L-type voltage-gated calcium channel (VGCC) activation in control animals, whereas in fear-conditioned animals HFS LTP is NMDAR- and VGCC-independent. LFS-LTP is partially NMDAR-dependent, but VGCCs are necessary for potentiation in fear memory. Collectively, these results show that during maintenance of fear memory the stimulus requirements for amygdala aff...Continue Reading

References

Dec 24, 1997·Nature·M G McKernan, P Shinnick-Gallagher
Apr 2, 1999·The European Journal of Neuroscience·N K Mahanty, P Sah
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·David L Walker, Michael Davis
May 25, 2002·The European Journal of Neuroscience·Markus Fendt, Susanne Schmid
Feb 1, 2003·Neurobiology of Learning and Memory·James L McGaughAnn E Power
May 2, 2003·Annals of the New York Academy of Sciences·Paul F ChapmanSimon G Knevett
May 2, 2003·Annals of the New York Academy of Sciences·Patricia Shinnick-GallagherFatiha Zinebi

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Citations

Oct 30, 2004·Synapse·Michael T Scott, Patricia Shinnick-Gallagher
Feb 18, 2014·Progress in Neurobiology·Raphael Lamprecht
May 10, 2006·Genes, Brain, and Behavior·C StoppelO Stork
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Amiel Rosenkranz
Sep 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin K OgdenScott A Heldt
Jul 15, 2009·Neurobiology of Learning and Memory·Brandon C McKinneyGeoffrey G Murphy
Oct 4, 2005·The European Journal of Neuroscience·Bradley W Schroeder, Patricia Shinnick-Gallagher
Sep 16, 2015·The International Journal of Neuropsychopharmacology·Monica Dines, Raphael Lamprecht
Aug 22, 2006·Neuropharmacology·Torfi SigurdssonJoseph E LeDoux
Nov 1, 2011·Cell·Joshua P JohansenJoseph E LeDoux
Oct 17, 2012·PloS One·Nathalie PhilippiFrédéric Blanc
Feb 27, 2013·Integrative Cancer Therapies·Sarah PrinslooLorenzo Cohen
Sep 26, 2006·Journal of Neuroscience Research·Alexandra Kavushansky, Gal Richter-Levin
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Apr 12, 2011·Reviews in the Neurosciences·Ingie HongSukwoo Choi
Aug 14, 2020·Cell and Tissue Research·Jens SchepersOliver von Bohlen Und Halbach
Nov 21, 2017·Neurobiology of Learning and Memory·Ryan G Parsons
Sep 19, 2006·Learning & Memory·David LebelElizabeth M Quinlan

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