Fear of pain in children and adolescents with neuropathic pain and complex regional pain syndrome

Pain
Laura E Simons

Abstract

A significant proportion of children and adolescents with chronic pain endorse elevated pain-related fear. Pain-related fear is associated with high levels of disability, depressive symptoms, and school impairment. Because of faulty nerve signaling, individuals with neuropathic pain and complex regional pain syndrome may be more prone to develop pain-related fear as they avoid use of and neglect the affected body area(s), resulting in exacerbated symptoms, muscle atrophy, maintenance of pain signaling, and ongoing pain-related disability. Not surprisingly, effective treatments for elevated pain-related fears involve exposure to previously avoided activities to downregulate incorrect pain signaling. In the context of intensive interdisciplinary pain treatment of youth with neuropathic pain, decreasing pain-related fear is associated with improved physical and psychological functioning, whereas high initial pain-related fear is a risk factor for less treatment responsiveness. An innovative approach to targeting pain-related fear and evidence of a neural response to treatment involving decoupling of the amygdala with key fear circuits in youth with complex regional pain syndrome suggest breakthroughs in our ability to ameliorate t...Continue Reading

References

Mar 1, 1996·Behaviour Research and Therapy·P MurisC Meesters
Aug 15, 2003·Archives of Physical Medicine and Rehabilitation·Jeanine A VerbuntJ Andre Knottnerus
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Susmita Kashikar-ZuckJonathan C Miller
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David C KnightFred J Helmstetter
Aug 26, 2004·Pain·Peter J Norton, Gordon J G Asmundson
Sep 15, 2004·Neuron·Elizabeth A PhelpsJoseph E LeDoux
Nov 13, 2004·Cognitive, Affective & Behavioral Neuroscience·David C KnightFred J Helmstetter
Jan 18, 2006·Biological Psychiatry·Francisco Sotres-BayonJoseph E LeDoux
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raffael KalischRaymond J Dolan
Dec 21, 2006·Journal of Behavioral Medicine·Maaike LeeuwJohan W S Vlaeyen
Jun 27, 2007·Psychological Bulletin·Robert J GatchelDennis C Turk
Aug 30, 2007·Nature Neuroscience·Andreas Olsson, Elizabeth A Phelps
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory J Quirk, Devin Mueller
Dec 15, 2007·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Andrea L MartinJoel Katz
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·Anna Huguet, Jordi Miró
Oct 10, 2008·Psychosomatic Medicine·Bruce D NaliboffEdward Ornitz
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catherine A Hartley, Elizabeth A Phelps
Apr 22, 2010·CNS Neuroscience & Therapeutics·Ansgar Rougemont-BückingMohammed R Milad
Oct 26, 2010·Pain·Kate M DunnLinda Le Resche
Mar 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Laura E SimonsCharles Berde
May 24, 2011·The Journal of Pain : Official Journal of the American Pain Society·Anna HuguetJudit Pardos
Jul 19, 2011·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Anna C WilsonTonya M Palermo
Oct 29, 2011·The Journal of Pain : Official Journal of the American Pain Society·Jeroen R de JongJaap Patijn
Dec 28, 2011·Biological Psychology·Tsafrir GreenbergLilianne R Mujica-Parodi
Jan 10, 2012·Current Opinion in Psychiatry·Herta Flor
Jan 11, 2012·Neuroscience and Biobehavioral Reviews·Caitlin A Orsini, Stephen Maren
Feb 11, 2012·Pain·Johan W S Vlaeyen, Steven J Linton

❮ Previous
Next ❯

Citations

Jul 20, 2016·Pain·Johan W S VlaeyenSteven J Linton
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Flavia Di PietroTasha R Stanton
Sep 19, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Benedetto LongoFabio Santanelli di Pompeo
Feb 4, 2014·Neuroscience Letters·Jaquette LiljencrantzHåkan Olausson
Aug 1, 2019·Clinical Child Psychology and Psychiatry·Peter M McInnisKasia Kozlowska
Dec 31, 2019·European Journal of Pain : EJP·Elke Van LierdeEva Van den Bussche
Feb 7, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Annina RiggenbachRémy Amouroux
Sep 15, 2020·The Clinical Journal of Pain·Abigail JonesAbbie Jordan
Jan 1, 2020·Neurobiology of Pain·S A HolmesD Borsook

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

Journal of the Indian Medical Association
Anup Kumar Bhattacharya
The Journal of Pain : Official Journal of the American Pain Society
Elizabeth CarpinoLaura E Simons
Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur
Andrea L MartinJoel Katz
© 2022 Meta ULC. All rights reserved