Fear response failed to return in AAB extinction paradigm accompanied with increased NR2B and GluR1 per845 in hippocampal CA1

Neuroscience
L XueH Zhao

Abstract

Extinction is a well-known and important behavioral phenomenon that allows an organism to adapt its behavior to its environment. Previous studies have shown that the expression of extinction is highly context dependent, meanwhile, conditioning context, as part of fear memory, might have influence on extinction formation. To this end, we have conducted four different extinction paradigms in this study: extinction conducted in the conditioning context but tested in another, novel context (AAB); conditioning in one context and extinction and testing in the second (ABB); conditioning in context A, extinction training in context B, but test back to context A (ABA); and extinction training in a third context, context C (ACB). Additionally, a low dose of the GABAA agonist muscimol was used to temporarily inactivate CA1 to observe its effect in extinction. Our results showed that rats under the AAB, but not the ACB or ABA condition, showed a similar level of freezing compared with the typical ABB extinction paradigm. Moreover, muscimol infused into CA1 before extinction training resulted in impaired extinction and down-regulation of NR2B activity and phosphorylated GluR1 (at Ser845) in CA1, and the expression levels of NR2B and GluR1 w...Continue Reading

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Citations

Mar 13, 2016·Biochemical and Biophysical Research Communications·Bing WangXiao-Guang Wang
Apr 19, 2015·Neuroscience and Biobehavioral Reviews·Elisabetta Baldi, Corrado Bucherelli
May 20, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dina PopovaNina N Karpova
Jul 18, 2019·Brain and Behavior·Yan-Wei ShiXue-Ling Ou
May 4, 2017·IUBMB Life·Weihai ChenHong Li
Aug 15, 2021·Behavioural Brain Research·Dong-Hee KimJung-Soo Han

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