Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites.

Malaria Journal
Ikeoluwapo O AjayiFranco Pagnoni

Abstract

The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings. Incorporation of ACT in HMM would greatly expand access to effective antimalarial therapy by the populations living in underserved areas in malaria endemic countries. The feasibility and acceptability of incorporating ACT in HMM needs to be evaluated. A multi-country study was performed in four district-size sites in Ghana (two sites), Nigeria and Uganda, with populations ranging between 38,000 and 60,000. Community medicine distributors (CMDs) were trained in each village to dispense pre-packaged ACT to febrile children aged 6-59 months, after exclusion of danger signs. A community mobilization campaign accompanied the programme. Artesunate-amodiaquine (AA) was used in Ghana and artemether-lumefantrine (AL) in Nigeria and Uganda. Harmonized qualitative and quantitative data collection methods were used to evaluate CMD performance, caregiver adherence and treatment coverage of febrile children with ACTs obtained from CMDs. Some 20,000 fever episodes in young children were treated with ACT by CMDs across the four study sites. Cross-...Continue Reading

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Citations

Apr 16, 2010·International Journal of Technology Assessment in Health Care·Pierre Ongolo-Zogo, Renée-Cécile Bonono
Apr 16, 2010·International Journal of Technology Assessment in Health Care·Harriet NabudereMalick Juma
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Feb 22, 2016·Malaria Journal·Lawrence G FebirSeth Owusu-Agyei

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