Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Alcoholism, Clinical and Experimental Research
Sandra W JacobsonJoseph L Jacobson

Abstract

Choline, an essential nutrient, serves as a methyl-group donor for DNA methylation and is a constituent of the neurotransmitter acetylcholine and a precursor to major components of cell membranes. Findings from animal studies suggest that choline supplementation during pregnancy can mitigate adverse effects of prenatal alcohol exposure on growth and neurocognitive function. We conducted a randomized, double-blind exploratory trial to examine feasibility and acceptability of a choline supplementation intervention during pregnancy. Seventy heavy drinkers, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of 2 g of choline or a placebo from time of enrollment until delivery. Each dose consisted of an individually wrapped packet of powder that, when mixed with water, produced a sweet tasting grape-flavored drink. Adherence was assessed by collecting used and unused drink packets on a monthly basis and tabulating the number used. Side effects were assessed in monthly interviews. Blood samples obtained at enrollment and at 4 and 12 weeks after randomization were assayed for plasma choline concentration. Adherence was good-to-excellent (median doses taken = 74.0%; interquartile range = 53.9 to 88.7%) and ...Continue Reading

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Citations

Jun 11, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa J AlldredStephen D Ginsberg
May 25, 2021·Clinical Nutrition ESPEN·M Camille HoffmanSharon K Hunter
Aug 4, 2021·Alcoholism, Clinical and Experimental Research·Fleur L WartonErnesta M Meintjes
Sep 9, 2021·Journal of Neurophysiology·Erin L GrafeBrian R Christie

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