Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Pilar HerreroRobert Gropler

Abstract

Nitric oxide (NO), the end product of the inducible form of NO synthase (iNOS), is an important mediator of a variety of inflammatory diseases. Therefore, a radiolabeled iNOS radiopharmaceutical for assessing iNOS protein concentration as a marker for its activity would be of value to the study and treatment of NO-related diseases. We recently synthesized an (18)F-radiolabeled analog of the reversible NOS inhibitor, 2-amino-4-methylpyridine ((18)F-NOS), and confirmed its utility in a murine model of lung inflammation. To determine its potential for use in humans, we measured (18)F-NOS myocardial activity in patients after orthotopic heart transplantation (OHT) and correlated it with pathologic allograft rejection, tissue iNOS levels, and calculated human radiation dosimetry. Two groups were studied-a kinetic analysis group and a dosimetry group. In the kinetic analysis group, 10 OHT patients underwent dynamic myocardial (18)F-NOS PET/CT, followed by endomyocardial biopsy. Myocardial (18)F-NOS PET was assessed using volume of distribution; standardized uptake values at 10 min; area under the myocardial moment curve (AUMC); and mean resident time at 5, 10, and 30 min after tracer injection. Tissue iNOS levels were measured by imm...Continue Reading

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Citations

Nov 1, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert J Gropler
Apr 9, 2008·Seminars in Nuclear Medicine·Douglas J Rowland, Simon R Cherry
Oct 4, 2016·Frontiers in Molecular Neuroscience·Pekka PoutiainenAnna-Liisa Brownell
Aug 10, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Heidi HögelLaura Airas
Dec 14, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shivesh GhuraRebecca L Ashare
Jan 17, 2020·Expert Review of Molecular Diagnostics·Evangelos K Oikonomou
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Matteo BaucknehtSilvia Morbelli
Jul 30, 2020·International Journal of Molecular Sciences·Gonçalo S ClementePhilip H Elsinga
Dec 20, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Howard J HuangDelphine L Chen
Sep 29, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Austin R PantelJoel S Karp
Mar 15, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sally W Schwarz, Reiko Oyama

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