PMID: 9531364Apr 8, 1998Paper

Feasibility and efficacy of external beam radiotherapy after hyperthermic isolated limb perfusion with TNF-alpha and melphalan for limb-saving treatment in locally advanced extremity soft-tissue sarcoma

International Journal of Radiation Oncology, Biology, Physics
A F OliemanH J Hoekstra

Abstract

Hyperthermic isolated limb perfusion (HILP) with tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and melphalan is associated with a dramatic antitumor effect in locally advanced extremity soft-tissue sarcomas (STS). The aim of this study was to demonstrate the feasibility and efficacy of adjuvant radiotherapy after HILP with TNF-alpha, IFN-gamma, and melphalan and delayed surgical resection. Between 1991 and 1995, 34 patients--16 males and 18 females, median age 50 (range 18-80) years--underwent HILP for locally advanced extremity STS. Resection of the residual tumor mass was performed in most patients after 6-8 weeks. Fifteen patients with histopathological viable tumor after resection received adjuvant 60-70 Gy external beam radiotherapy (EBRT) (44%, HILP + EBRT group). Nineteen patients received HILP without adjuvant EBRT (56%, HILP-only group). Five patients in the HILP-only group had also distant metastases (15%) and received HILP as a palliative treatment. Treatment morbidity, local recurrences, and regional and distant metastases were scored. During a median follow-up of 34 months (range 8-54), limb salvage was achieved in 29 patients (85%): 14 patients after HILP + EBRT and 15 patients after HILP ...Continue Reading

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Citations

Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P H NijhuisH J Hoekstra
Oct 31, 1998·Current Opinion in Immunology·F J LejeuneD Liénard
Aug 18, 2004·Annals of Surgical Oncology·Eva M NoordaBin B R Kroon
Nov 27, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marco RastrelliCarlo Riccardo Rossi
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G TaegerS Ruchholtz
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan P DerooseCornelis Verhoef
Jun 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BonvalotA Le Cesne
Feb 8, 2006·Nature Clinical Practice. Oncology·Dirk J GrünhagenAlexander M M Eggermont
May 10, 2001·Journal of Surgical Oncology·J W FinleyJ F Gibbs
Apr 15, 2006·The Oncologist·Remco van HorssenAlexander M M Eggermont
Jul 23, 1999·Current Opinion in Oncology·L Y Dirix, A T Van Oosterom
Jun 9, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Valerio BelgranoRoger Olofsson Bagge

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