Feasibility and morbidity of using saline filled tissue expanders to reduce radiation-induced bowel injury in patients with gynecologic malignancies

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Melissa A GellerMatthew P Boente

Abstract

To evaluate the feasibility and morbidity of using saline filled tissue expanders (TE) to displace the small bowel during radiation therapy in patients with gynecologic malignancies. Ten patients undergoing surgical exploration for a gynecologic malignancy and deemed to be at high risk for the late effects of radiation therapy were consented for the possible placement of a TE. Indication for placement was need for post-operative radiation. Small bowel exclusion was reported in terms of the lowest loop identified on treatment planning film using orally ingested barium. Small bowel loops were excluded from the pelvis to varying degrees in all patients. Lowest identifiable bowel was marked at the L4-L5 interspace in one patient, L5-S1 interspace in three patients, at or near the sacral promontory in three patients, and to the middle of S2 in one patient. In two patients the TE was removed prior to simulation. Early complications included migration of the TE during treatment, development of a vesicovaginal fistula requiring immediate removal of the TE, and enterocutaneous fistula formation in a patient who developed an abscess following treatment completion. Another patient experienced a rectovaginal fistula 18 months after removal...Continue Reading

References

Sep 1, 1987·Gynecologic Oncology·M PenalverR Girtanner
Oct 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R G BourneS J Roberts
Mar 15, 1982·Cancer·W M HoganJ J Mikuta
Apr 1, 1982·American Journal of Clinical Oncology·R A Potish
Jan 1, 1995·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·R HolstE Goldschmidt
Dec 20, 2000·American Journal of Obstetrics and Gynecology·R MirhashemiM Penalver
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia J EifelHoward Thames
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Mustafa AdliJohn M Buatti

❮ Previous
Next ❯

Citations

Jun 29, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J M AliN S Fearnhead
Oct 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I Pérez-MuñozL Jeys
Dec 14, 2011·Gynecologic Oncology·Aaron H WolfsonUNKNOWN American College of Radiology (ACR)
Dec 23, 2014·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Sabine IrtanSabine Sarnacki
Dec 31, 2009·Journal of Gynecologic Oncology·Mark A RettenmaierBram H Goldstein
Oct 20, 2015·Journal of Pediatric Hematology/oncology·Shuichiro UeharaHiroomi Okuyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Oncology : a Journal of the Royal College of Radiologists
A Taylor, M E B Powell
International Journal of Radiation Oncology, Biology, Physics
S ZuninoD Venencia
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Q D PieterseG G Kenter
International Journal of Radiation Oncology, Biology, Physics
John C RoeskeArno J Mundt
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
John C RoeskeArno J Mundt
© 2022 Meta ULC. All rights reserved