Feasibility and reproducibility of whole brain myelin water mapping in 4 minutes using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) at 3T

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Thanh D NguyenSusan A Gauthier

Abstract

To develop and measure the reproducibility of 4-min whole brain myelin water fraction (MWF) mapping using fast acquisition with spiral trajectory and T2prep (FAST-T2) sequence at 3T. Experiments were performed on phantoms, 13 volunteers, and 16 patients with multiple sclerosis. MWF maps were extracted using a spatially constrained non-linear algorithm. The proposed adiabatic modified BIR-4 (mBIR-4) T2prep was compared with the conventional composite T2prep (COMP). The effect of reducing the number of echo times (TEs) from 15 to 6 (reducing scan time from 10 to 4 min) was evaluated. Reproducibility was assessed using correlation analysis, coefficient of variation (COV), and Bland-Altman plots. Compared with COMP, mBIR-4 provided more accurate T2 in phantoms and better MWF maps in human brains. Reducing the number of TEs had a negligible effect on MWF map quality, with a regional MWF difference of <0.8%. Regional MWFs obtained by repeated scans showed excellent correlation (R = 0.99), low COV (1.3%-2.4%), and negligible bias within ±1% limits of agreement. On a voxel-wise basis, the agreement remained strong (correlation R = 0.89 ± 0.03, bias = 0.01% ± 0.29%, limits of agreement = [-3.35% ± 0.73%, 3.33% ± 0.61%]). Whole brain MWF...Continue Reading

References

May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J H BrittainD G Nishimura
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A Bottomley, R Ouwerkerk
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J GrahamM J Bronskill
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K P WhittallD W Paty
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
May 9, 2006·Magnetic Resonance Imaging·Alex MacKayBurkhard Mädler
Sep 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Cornelia LauleAlex L MacKay
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yiping P DuJack H Simon
Jan 1, 1991·IEEE Transactions on Medical Imaging·D C NollA Macovski
Feb 28, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Piotr KozlowskiWolfram Tetzlaff
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean C L DeoniDerek K Jones
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shannon H KolindAlex L MacKay
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hao Tan, Craig H Meyer
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Antoine LuttiNikolaus Weiskopf
Jun 30, 2011·The Neurologist·Guy PoloniRobert Zivadinov
Oct 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas PrasloskiCraig Jones
Dec 14, 2011·NeuroImage·Shannon KolindJackie Palace
Dec 27, 2011·Journal of Magnetic Resonance·G WangP A Bottomley
Jan 24, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dushyant KumarAshish Raj
Feb 22, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thanh D NguyenSusan A Gauthier
Jul 11, 2012·NeuroImage·Thomas PrasloskiBurkhard Mädler
Dec 6, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elizabeth R JenistaRaymond J Kim
Apr 5, 2013·Journal of Magnetic Resonance Imaging : JMRI·Sandra M MeyersCornelia Laule
Jun 1, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanMichael Schacht Hansen
Mar 8, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eva Alonso-OrtizG Bruce Pike

❮ Previous
Next ❯

Citations

Oct 29, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peng CaoPeder E Z Larson
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Jul 13, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mustapha BouhraraRichard G Spencer
Feb 15, 2020·Annals of Neurology·Russell OuelletteTobias Granberg
Jun 25, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sneha PandyaSusan A Gauthier
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gian Franco PireddaTobias Kober
Apr 12, 2016·NMR in Biomedicine·Jongho LeeDong-Hyun Kim
Jun 14, 2017·Therapeutic Advances in Neurological Disorders·Ulrike W Kaunzner, Susan A Gauthier
Dec 21, 2016·Brain Plasticity·Alex L MacKay, Cornelia Laule
Nov 18, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gerhard S DrenthenJacobus F A Jansen
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Matteo BaucknehtSilvia Morbelli
Jul 29, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gian Franco PireddaTobias Kober
Dec 29, 2020·NeuroImage. Clinical·Po-Jui LuCristina Granziera
Nov 16, 2020·NeuroImage·Chris W J van der WeijdenErik F J de Vries
Mar 12, 2021·Brain : a Journal of Neurology·Reza RahmanzadehCristina Granziera
May 11, 2021·Brain : a Journal of Neurology·Cristina GranzieraUNKNOWN MAGNIMS Study Group
Aug 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Sandra M Hurtado RúaSusan A Gauthier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Eva Alonso-OrtizG Bruce Pike
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Tamer A BashaReza Nezafat
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Victor CasulaMiika T Nieminen
© 2021 Meta ULC. All rights reserved