PMID: 16508392Mar 2, 2006Paper

Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study

Anesthesiology
G LockwoodMervyn Maze

Abstract

Postoperative neurocognitive deficit is prevalent after cardiac surgery. Xenon may prevent or ameliorate acute neuronal injury, but it also may aggravate injury during cardiac surgery by increasing bubble embolism. Before embarking on a randomized clinical trial to test the safety and efficacy of xenon for postoperative neurocognitive deficit, we undertook a phase I study to investigate the safety of administering xenon to patients undergoing coronary artery bypass grafting while on cardiopulmonary bypass and to assess the practicability of our xenon delivery system. Sixteen patients scheduled for coronary artery bypass grafting surgery with hypothermic cardiopulmonary bypass gave their informed consent to participate in an open-label dose-escalation study (0, 20, 35, 50% xenon in oxygen and air). Xenon was delivered throughout surgery using both a standard anesthetic breathing circuit and the oxygenator. Gaseous and blood xenon partial pressures were measured five times before, during, and after cardiopulmonary bypass. Middle cerebral artery Doppler was used to assess embolic load, and major organ system function was assessed before and after surgery. Middle cerebral artery Doppler showed no evidence of increased emboli with x...Continue Reading

References

Jul 20, 1981·Biochimica Et Biophysica Acta·R A SmithK W Miller
May 29, 1998·British Journal of Anaesthesia·T GotoS Morita
Dec 9, 1998·Nature·N P FranksW R Lieb
Feb 15, 2001·The New England Journal of Medicine·M F NewmanUNKNOWN Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·M F NewmanUNKNOWN Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Hear
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·David R Lynch, Rodney P Guttmann
Aug 10, 2002·Anesthesiology·Stefan WilhelmNicholas P Franks
Oct 16, 2002·British Journal of Anaesthesia·G Lockwood
Oct 24, 2002·British Journal of Anaesthesia·D MaN P Franks
Feb 25, 2003·Life Sciences·Christian PetzeltWolfgang J Kox
Sep 10, 2003·Anesthesiology·Naomi Sta Maria, David M Eckmann
Apr 27, 2005·Anesthesiology·Michael SchmidtUwe Schirmer
May 28, 2005·European Journal of Anaesthesiology·H P GrocottB E Smith
Jun 16, 2005·Acta Anaesthesiologica Scandinavica·J-H BaumertR Rossaint
Jul 22, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daqing MaMervyn Maze
Jul 29, 2005·Annals of Neurology·Daqing MaMervyn Maze

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Citations

Aug 8, 2007·Journal of Anesthesia·Hilary P Grocott, Kenji Yoshitani
Sep 15, 2010·Critical Care : the Official Journal of the Critical Care Forum·Robert Dickinson, Nicholas P Franks
Jul 11, 2006·Current Opinion in Anaesthesiology·Peter H Tonner
Aug 28, 2012·European Journal of Anaesthesiology·Stuart D FaulknerNicola J Robertson
Apr 12, 2008·Expert Review of Cardiovascular Therapy·Niamh ConlonG Burkhard Mackensen
Oct 29, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mervyn Maze
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel
Nov 5, 2014·British Journal of Pharmacology·Kirsten F SmitBenedikt Preckel
Jan 21, 2014·Progress in Neurobiology·Jiao DengLize Xiong
Mar 26, 2015·International Anesthesiology Clinics·Galina Korsunsky
Jun 27, 2008·Anesthesiology·Thomas Marx
Oct 27, 2006·Anesthesiology·David M Eckmann
Jun 14, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hailin ZhaoDaqing Ma
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Walter M van den Bergh
Nov 24, 2019·Molecular Neurobiology·Mervyn Maze, Timo Laitio
Mar 10, 2020·Interventional Medicine & Applied Science·Daniel G JovinBenita Dharmaraj

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