Feasibility and safety of non-invasive ultrasound therapy (NIUT) on porcine aortic valve.

Physics in Medicine and Biology
Emmanuel MessasMathieu Pernot

Abstract

Calcific aortic stenosis (CAS) is associated with advanced age and comorbidities, therefore a non-invasive therapy would be beneficial. We previously demonstrated that ultrasound therapy (UT) improved calcified bioprosthetic valves function, in open chest model. For translational application, we tested Non-Invasive Ultrasound Therapy (NIUT) transthoracically on swine's aortic valves and the need of antithrombotic treatment at follow-up. Primary objective: feasibility and safety of NIUT. Secondary objectives: occurrence, severity and evolution of side effects during therapy and one-month follow-up. The device (Valvosoft®, Cardiawave) consisted of a multi-element transducer steered electronically and a 2D echocardiographic probe. Three groups of swine received treatment on aortic valves: NIUT (group 1; n=10); NIUT and one-month antithrombotic treatment (group 2; n=5); sham group (group 3; n=4). Feasibility was successfully reached in all treated swine (n=15) and no life-threatening arrhythmia were detected. Non-sustained ventricular tachycardia (NSVT) occurred during procedure in 7 swine. Decrease or interruption of NIUT ended arrhythmia. Histopathology revealed no valve or surrounding tissues damage and echocardiography no valvu...Continue Reading

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