Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea

The Korean Journal of Internal Medicine
Dae Geon AhnJune Sung Lee

Abstract

The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients. We retrospectively reviewed the medical records of HCC and cirrhosis patients at three hospitals. For each HCC patient, a cirrhosis patient matched for age, sex, etiology, and Child-Pugh classification was selected by simple random sampling. The performance of AFP in the diagnosis of HCC was determined using receiver operating characteristic curve analysis. A total of 732 patients with HCC or cirrhosis were selected for each case and the control groups. The mean age was 54 years, and 72.4% of patients were male. The mean serum AFP levels in the HCC group and cirrhosis group were 3,315.6 and 117.2 ng/mL, respectively (p < 0.001). The area under the receiver operating characteristic curve for all HCC patients was 0.757. The sensitivity, specificity, and positive predictive value of AFP was 50.55%, 87.70%, and 80.43%, respectively, at a cut-off of 20 ng/mL; 37.70%, 95.90%, and 90.20%, respectively, at a cut-off of 100 ng/mL, and 30.05%, 97.27%, and 91.67%, respectively, at a cut-off of 200 ng/mL. A cut-off of 100 ng/mL was more sensitive than one of 200 ng/mL with equivalent speci...Continue Reading

References

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Collier, M Sherman
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mindie H NguyenEmmet B Keeffe
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rosario F VelázquezLuis Rodrigo
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Feb 4, 2010·Clinics in Liver Disease·Helen S Te, Donald M Jensen
Apr 17, 2010·Digestive Diseases and Sciences·Faisal M SanaiAyman A Abdo
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jun 22, 2011·Clinics in Liver Disease·Katherine A McGlynn, W Thomas London
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Apr 5, 2013·World Journal of Gastroenterology : WJG·Chang LiuJia-Yin Yang
Jun 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A A Terentiev, N T Moldogazieva
Aug 29, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Stephen L ChanSimon C H Yu
Jun 17, 2014·Internal Medicine·Noriko MatsushitaHiroshi Murayama

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Stephen L ChanSimon C H Yu
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jen-Eing JengJung-Fa Tsai
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
J F TsaiC Y Dai
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Edoardo G GianniniItalian Liver Cancer (ITA.LI.CA) group
© 2022 Meta ULC. All rights reserved