Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: the LaCeS feasibility trial protocol

BMJ Open
Deena HarjiPeter Sagar

Abstract

Acute colorectal surgery forms a significant proportion of emergency admissions within the National Health Service. There is limited evidence to suggest minimally invasive surgery may be associated with improved clinical outcomes in this cohort of patients. Consequently, there is a need to assess the clinical effectiveness and cost-effectiveness of laparoscopic surgery in the acute colorectal setting. However,emergency colorectal surgical trials have previously been difficult to conduct due to issues surrounding recruitment and equipoise. The LaCeS (randomised controlled trial of Laparoscopic versus open Colorectal Surgery in the acute setting) feasibility trial will determine the feasibility of conducting a definitive, phase III trial of laparoscopic versus open acute colorectal resection. The LaCeS feasibility trial is a prospective, multicentre, single-blinded, parallel group, pragmatic randomised controlled feasibility trial. Patients will be randomised on a 1:1 basis to receive eitherlaparoscopic or open surgery. The trial aims to recruit at least 66 patients from five acute general surgical units across the UK. Patients over the age of 18 with a diagnosis of acute colorectal pathology requiring resection on clinical and r...Continue Reading

References

Aug 1, 1992·The British Journal of Surgery·O J McAnenaJ Fitzpatrick
Aug 7, 2002·Surgical Endoscopy·E J Hazebroek, UNKNOWN Color Study Group
Mar 17, 2004·Controlled Clinical Trials·Heejung BangClarence E Davis
Jun 11, 2004·Journal of Evaluation in Clinical Practice·Gillian A LancasterPaula R Williamson
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·E J Dawson, S Paterson-Brown
Jun 3, 2008·World Journal of Emergency Surgery : WJES·Tuong A Mai-PhanHemant M Kocher
Jun 12, 2009·Surgical Endoscopy·Hong-Bo WeiTian-Bao Wang
Jun 8, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G A BindaUNKNOWN Study Group on Diverticulitis
Sep 19, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Fawzi al-AyoubiPeter Andersson
Jul 12, 2013·The British Journal of Surgery·UNKNOWN National Surgical Research Collaborative
Jul 19, 2013·The British Journal of Surgery·N R A SymonsO D Faiz
Nov 29, 2013·The British Journal of Surgery·D P HarjiP M Sagar
Sep 7, 2016·Perioperative Medicine·Peter M Odor, Michael P W Grocott

❮ Previous
Next ❯

Citations

Jun 24, 2020·The British Journal of Surgery·D P HarjiUNKNOWN LaCeS Collaborators
Mar 1, 2020·International Journal of Colorectal Disease·Kheng-Seong NgDavid G Jayne
Jun 11, 2020·Updates in Surgery·Richa PatelAziz M Merchant

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
surgical resection
dissection

Software Mentioned

LaCeS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.