Feasibility of a novel radiofrequency signal analysis for in-vivo plaque characterization in humans: comparison of plaque components between patients with and without acute coronary syndrome

International Journal of Cardiology
Amane KozukiKen-ichi Hirata

Abstract

The iMAP™ is a novel intravascular ultrasound (IVUS)-based technology to classify coronary plaque into 4 components. The aim of this study was to evaluate the feasibility of iMAP™ technology by comparing plaque characteristics in patients with and without acute coronary syndrome (ACS and non-ACS). A total of 93 culprit lesions from 87 patients were analyzed using the iMAP™. Each plaque was classified into 4 components with a newly introduced parameter, confidence level (CL). iMAP™ analysis of the minimal lumen cross-sectional area (MLA) revealed that ACS lesions had significantly larger lipidic and necrotic areas than non-ACS lesions. Multivariate analysis revealed that the lipidic area at the MLA was an iMAP™ factor independently associated with ACS lesions (odds ratio -1.5, p=0.04). Based on receiver operating characteristic analysis with 4 different CL ranges, the lipidic area at the MLA with 25%-100% CL had the largest area under the curve (0.756), suggesting that 25%-100% is the best CL range for identifying ACS culprit lesions. The feasibility of the novel iMAP™ IVUS system was shown in discriminating culprit lesions in patients with and without ACS. Analyzing with a CL of 25%-100% may be the best option for discriminatin...Continue Reading

References

Nov 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·R J PetersC A Visser
Sep 13, 2002·Journal of the American College of Cardiology·Akiko MaeharaNeil J Weissman
Dec 6, 2005·Journal of the American College of Cardiology·Gastón A Rodriguez-GranilloPatrick W Serruys
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
Oct 24, 2007·Journal of the American College of Cardiology·Ren KawaguchiKoichi Taniguchi
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Shashidhar SathyanarayanaLewis Thomas
Nov 10, 2009·International Journal of Cardiology·Shinobu KojimaHisao Ogawa

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Citations

Nov 6, 2015·Journal of Zhejiang University. Science. B·Jian LiuHong Zhao
Aug 21, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Seiji KogaKoji Maemura
Mar 23, 2017·Journal of Atherosclerosis and Thrombosis·Akane MatsumotoShinji Kihara
Feb 23, 2020·The International Journal of Cardiovascular Imaging·Jianchang XieJinyu Huang

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