Feasibility of a practical clinical trial for asthma conducted in primary care

The Journal of the American Board of Family Practice
David L Hahn, Mary Beth Plane

Abstract

Practical clinical trials (PCTs) are essential to generate relevant evidence-based information to improve patient health. Primary care physicians' experience performing randomized controlled trials (RCTs) on representative patient populations is limited. We implemented a pilot practice-based asthma PCT to answer the following feasibility questions: (1) Was clinician interest initiated and maintained? (2) Did clinicians enroll patients into an RCT and complete follow-up? (3) Was an interactive voice-response (IVR) telephone system useful to collect patient-reported data? The protocol included (1) broadly representative adult asthma eligibility criteria, (2) self-reported patient-oriented outcomes, and (3) use of IVR to collect these data. Physicians in practice-based research networks, managed care organizations, and academic networks volunteered to participate. Of 13 physician volunteers, 10 (8 single-person office practices, 1 emergency department physician, 1 clinical researcher) from 4 states and 1 Canadian province enrolled 58 subjects and randomized 45 meeting final eligibility criteria; 39 (87%) attended the follow-up visit. However, only 34 (76%) provided adequate follow-up IVR self-report data, and subjects with less th...Continue Reading

Citations

May 7, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Paul Ehrlich, UNKNOWN BCBL Panel of the Asthma and Allergy Foundation of America
Nov 28, 2008·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Neale R ChumblerTerry Rabinowitz
Jul 28, 2006·PLoS Clinical Trials·David L HahnGerald I Byrne
Dec 2, 2009·Journal of Chiropractic Medicine·Michael T Haneline, Robert Cooperstein
Apr 3, 2007·Contemporary Clinical Trials·Khamis Abu-HasaballahRobert H Aseltine

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