Feasibility of biodegradable PLGA common bile duct stents: an in vitro and in vivo study.

Journal of Materials Science. Materials in Medicine
Xiaoyi XuXiabin Jing

Abstract

The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(L-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4-5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.

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Citations

Nov 19, 2013·Journal of Materials Science. Materials in Medicine·Yigang ChenQi Zheng
Aug 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yigang ChenQi Zheng
Sep 29, 2011·Gastrointestinal Endoscopy·Jeffrey L TokarSarah A Rodriguez
Sep 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Edouard GirardBenjamin Nottelet
Nov 7, 2019·Nanomaterials·Kateřina ŠkrlováDaniela Plachá
Nov 14, 2013·Experimental and Therapeutic Medicine·Yigang ChenQi Zheng
Jul 10, 2021·Cardiovascular and Interventional Radiology·Chu-Hui ZengGao-Jun Teng

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