Feasibility of catheter-directed intraluminal irreversible electroporation of porcine ureter and acute outcomes in response to increasing energy delivery

Journal of Vascular and Interventional Radiology : JVIR
Govindarajan SrimathveeravalliJeremy C Durack

Abstract

To evaluate the feasibility of focal intraluminal irreversible electroporation (IRE) in the ureter with a novel electrode catheter and to study the treatment effects in response to increasing pulse strength. Five IRE treatment settings were each evaluated twice for the ablation of normal ureter in 5 Yorkshire pigs (n = 1-4 ablations per animal; total of 10 ablations) with the use of a prototype device under ultrasound and fluoroscopic guidance. Animals received unilateral or bilateral treatment, limited to a maximum of 2 ablations in any 1 ureter. Treatment was delivered with increasing pulse strength (from 1,000 V to 3,000 V in increments of 500 V) while keeping the pulse duration (100 μs) and number of pulses (n = 90) constant. Ureter patency was assessed with antegrade ureteropyelography immediately following treatment. Animals were euthanized within 4 hours after treatment, and treated urinary tract was harvested for histopathologic analysis with hematoxylin and eosin and Masson trichrome stains. IRE was successfully performed in all animals, without evidence of ureteral perforation. Hematoxylin and eosin analysis of IRE treatments demonstrated full-thickness ablation at higher field strengths (mucosa to the adventitia). Ma...Continue Reading

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Citations

Apr 25, 2019·American Journal of Physiology. Renal Physiology·Eisuke UeshimaGovindarajan Srimathveeravalli
Aug 28, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Fenggang RenYi Lv
Jul 23, 2020·Journal of Hepato-biliary-pancreatic Sciences·Qingshan LiYi Lv
Mar 4, 2020·International Urology and Nephrology·Laurien G P H VroomenGovindarajan Srimathveeravalli
Aug 14, 2020·Cancers·Aleksander KiełbikJulita Kulbacka
Mar 9, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T RohanS Nahum Goldberg

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