Feasibility of Classification of Triple Negative Breast Cancer by Immunohistochemical Surrogate Markers

Clinical Breast Cancer
Sewha KimSun Hee Sung

Abstract

Recently, Burstein et al identified 4 stable molecular subtypes of triple negative breast cancer (TNBC) by mRNA profiling: luminal androgen receptor (LAR), mesenchymal (MES), basal-like immune-activated (BLIA), and basal-like immune-suppressive (BLIS) types. The purpose of this study was to assess the feasibility of immunohistochemistry (IHC) surrogate panel in classifying the TNBC molecular subtypes using a large cohort of TNBC retrieved from a single institution. IHC for androgen receptor [AR], claudin-3, E-cadherin, cytokeratin 5/6 [CK5/6], epidermal growth factor receptor [EGFR], indoleamine 2,3-dioxygenase 1 [IDO1], and Forkhead box C1 [FOXC1] were performed using the tissue microarray constructed from 200 TNBC samples. The 200 TNBCs were classified as LAR (AR+, n = 22; 11.0%), MES (claudin 3- and/or E-cadherin-, n = 23; 11.5%), basal-like (CK5/6+ and/or EGFR+, n = 85; 42.5%), mixed (n = 60; 30%), and unclassifiable type (n = 10; 5%). LAR type was associated with older patient age, apocrine histologic features, low density of stromal tumor-infiltrating lymphocytes (TIL), and low Ki-67 labeling index. MES type was associated with tumor cell discohesiveness and metaplastic features. Basal-like type was associated with younge...Continue Reading

Citations

Apr 4, 2019·Frontiers in Genetics·Erika Bandini, Francesca Fanini
Mar 13, 2019·Journal of Clinical Medicine·Swapnil C KambleSharmila A Bapat
Jan 17, 2020·British Journal of Cancer·Jessica C CascianoZachary T Schug
Jul 19, 2020·Pathology Oncology Research : POR·Hulya Sahin OzkanHandan Kaya
Sep 29, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carmen Salvador-ColomaJaime Font de Mora
Dec 19, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sandeep KumarGurpreet Singh
May 7, 2021·Breast Cancer Research and Treatment·Sandeep KumarGurpreet Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

Journal of Clinical and Diagnostic Research : JCDR
Chandrika RaoKishan Hl Prasad
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Robert KornegoorPaul J van Diest
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hye Min KimJa Seung Koo
© 2022 Meta ULC. All rights reserved