Feasibility of CXCR4-Directed Radioligand Therapy in Advanced Diffuse Large B-Cell Lymphoma

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Constantin LapaGötz Ulrich Grigoleit

Abstract

We have recently reported on our experience with C-X-C-motif chemokine receptor 4 (CXCR4)-directed radioligand therapy (RLT) in multiple myeloma and acute leukemia. Methods: Six patients with heavily pretreated relapsed diffuse large B-cell lymphoma (3 men, 3 women; aged, 54 ± 8 y) underwent CXCR4-directed RLT in combination with conditioning chemotherapy and allogeneic stem cell transplantation. In 2 patients, radioimmunotherapy targeting CD20 or CD66 was added to enhance antilymphoma activity. Endpoints were incidence and severity of adverse events, progression-free survival, and overall survival. Results: RLT and additional radioimmunotherapy were well tolerated, without any acute adverse events or changes in vital signs. Successful engraftment was recorded after a median of 11 d (range, 9-13 d). Of the 4 patients who were available for follow-up (one patient died of CNS aspergillosis 29 d after RLT and another of sepsis in aplasia 34 d after RLT), CXCR4-directed RLT resulted in a partial response in two (both treated with additional radioimmunotherapy) and a mixed response in the remaining two. The response duration was rather short-lived, with a median progression-free survival of 62 d (range, 29-110 d) and a median overal...Continue Reading

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Citations

Feb 2, 2019·Current Topics in Medicinal Chemistry·Nan LiuYue Chen
Feb 6, 2020·Pharmaceuticals·Christine Rangger, Roland Haubner
Aug 15, 2018·Annals of Nuclear Medicine·Malte KircherConstantin Lapa
Sep 3, 2019·Frontiers in Oncology·Rudolf A WernerConstantin Lapa
Feb 14, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Philipp LindeCarsten Kobe
Nov 20, 2020·Journal of Clinical Medicine·Anna YordanovaHojjat Ahmadzadehfar
Apr 4, 2021·Diagnostics·Alexander WeichMalte Kircher
Mar 10, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sabine MaurerConstantin Lapa
Oct 28, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Malte KircherXiang Li
Jan 12, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lilja B SolnesSteven P Rowe
Apr 26, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter HerhausUlrich Keller
Oct 16, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zhenying ChenWeibing Miao
Jun 12, 2021·Clinical Nuclear Medicine·Zhenying ChenWeibing Miao
May 30, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sabrina KrausConstantin Lapa

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