Feasibility of diffuse optical imaging with long-lived luminescent probes.

Optics Letters
Sofia V AprelevaS A Vinogradov

Abstract

Long-lived near-infrared phosphors with high quantum yields have recently become available, making it possible to image oxygen distributions in tissue in three dimensions. By numerical simulations we demonstrate that, by using phosphorescent probes with appropriate oxygen quenching constants, one can image hypoxic phantoms in scattering media with adequate spatial resolution, employing simple time-gated measurements. The approach developed will guide experimental imaging of phosphorescence lifetime and oxygen pressure in living tissue.

References

Jul 2, 2002·Nature Medicine·Vasilis NtziachristosRalph Weissleder
Feb 22, 2005·Current Opinion in Biotechnology·Andreas H Hielscher
Dec 1, 1994·Optics Letters·E M Sevick-Muraca, C L Burch
Jan 15, 1996·Optics Letters·M A O'LearyA G Yodh

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Citations

Apr 2, 2010·ACS Applied Materials & Interfaces·Rajiv KumarParas N Prasad
Aug 2, 2008·IEEE Transactions on Medical Imaging·Anand T N KumarDavid A Boas
Jun 19, 2013·Chemical Society Reviews·Dmitri B Papkovsky, Ruslan I Dmitriev
Nov 7, 2006·Applied Optics·Sovia V AprelevaSergei A Vinogradov
Jun 30, 2018·Optics Letters·Anand T N Kumar, Steven S Hou
Sep 25, 2021·Chemical Reviews·Yuyan Jiang, Kanyi Pu

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