Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man.

Frontiers in Physiology
Alun D HughesKim H Parker

Abstract

Wave intensity analysis provides valuable information on ventriculo-arterial function, hemodynamics, and energy transfer in the arterial circulation. Widespread use of wave intensity analysis is limited by the need for concurrent measurement of pressure and flow waveforms. We describe a method that can estimate wave intensity patterns using only non-invasive pressure waveforms (pWIA). Radial artery pressure and left ventricular outflow tract (LVOT) flow velocity waveforms were recorded in 12 participants in the Southall and Brent Revisited (SABRE) study. Pressure waveforms were analyzed using custom-written software to derive the excess pressure (P xs ) which was scaled to peak LVOT velocity and used to calculate wave intensity. These data were compared with wave intensity calculated using the measured LVOT flow velocity waveform. In a separate study, repeat measures of pWIA were performed on 34 individuals who attended two clinic visits at an interval of ≈1 month to assess reproducibility and reliability of the method. P xs waveforms were similar in shape to aortic flow velocity waveforms and the time of peak P xs and peak aortic velocity agreed closely. Wave intensity estimated using pWIA showed acceptable agreement with esti...Continue Reading

References

Aug 1, 1990·Journal of Biomechanical Engineering·K H Parker, C J Jones
Jan 1, 1997·Heart and Vessels·J M MacRaeJ V Tyberg
Feb 12, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Miguel A QuiñonesUNKNOWN Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jiun-Jr WangJohn V Tyberg
Jul 15, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M Bland, D G Altman
Feb 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·A ZambaniniA D Hughes
Aug 16, 2006·The Journal of Nervous and Mental Disease·Domenic CicchettiPeter Tyrer
Feb 12, 2009·Medical & Biological Engineering & Computing·Kim H Parker
Oct 31, 2012·Computer Methods and Programs in Biomedicine·Bernhard HametnerThomas Weber
Jul 1, 2016·Journal of cardiovascular ultrasound·Jin-Oh ChoiSeung Woo Park
Oct 26, 2018·Journal of Applied Physiology·Gary F Mitchell

❮ Previous
Next ❯

Citations

Sep 26, 2020·Frontiers in Physiology·Jonathan P MynardJoseph J Smolich
Oct 9, 2020·Journal of Hypertension·Matthew K ArmstrongJames E Sharman

❮ Previous
Next ❯

Software Mentioned

Stata
SphygmoCor
ARCSolver
Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.