Feasibility of Extended-interval Follow-up for Patients Receiving Warfarin

Cardiovascular Therapeutics
Nicholas W CarrisEric Dietrich

Abstract

The 2012 American College of Chest Physician Evidence-Based Management of Anticoagulant Therapy guidelines suggest an international normalized ratio (INR) testing interval of up to 12 weeks, rather than every 4 weeks, for patients with consistently stable INRs while taking vitamin K antagonists. We aimed to examine the feasibility of extended-interval follow-up in a real-world setting. Patients receiving stable warfarin therapy for ≥ 12 weeks at baseline began extended-interval follow-up with visits occurring at 6 weeks, 14 weeks, and every 12 weeks thereafter to a maximum of 68 weeks or until they were no longer suitable for extended-interval follow-up. A single INR excursion >0.3 from goal was permitted if a reversible precipitating factor was identified and the INR was expected to return to goal without dose adjustment. The primary outcome was the proportion of patients completing all study follow-up visits. Of 48 patients enrolled, 47 had evaluable data. The most common indication for anticoagulation was atrial fibrillation/flutter (53.2%). At baseline, mean prior warfarin treatment duration was 6.7 ± 6 years and median number of weeks on a stable regimen was 24 weeks (IQR, 19-37.5). Eleven patients (23%) completed all stud...Continue Reading

References

Jun 20, 2008·Journal of Thrombosis and Thrombolysis·Larisa H CavallariEdith A Nutescu
May 15, 2009·Blood·Daniel M WittUNKNOWN Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium
Apr 20, 2010·Journal of Thrombosis and Haemostasis : JTH·D M WittUNKNOWN Warped Consortium

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Citations

Jun 3, 2016·Journal of Thrombosis and Thrombolysis·Nicholas W CarrisKatherine Vogel Anderson
Nov 3, 2016·Journal of Thrombosis and Thrombolysis·Andrea L PorterChristopher D Fletcher
Jun 3, 2018·The Annals of Pharmacotherapy·Andrew Y HwangSteven M Smith
Oct 8, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Amanda R MargolisCheryl A Ray
Nov 23, 2019·The Annals of Pharmacotherapy·Rebecca R SchoenAmanda R Margolis
May 28, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Chia Siang KowSyed Shahzad Hasan

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