Feasibility of gastric electrical stimulation by percutaneous endoscopic transgastric electrodes

Gastrointestinal Endoscopy
Hanaa S SallamPankaj J Pasricha

Abstract

Gastric electrical stimulation has been used for the treatment of drug refractory GI motility disorders and for the treatment of obesity. Both these indications have involved surgical placement of gastric electrodes, which adds to the complexity and cost of the procedure. Endoscopic placement is therefore an attractive alternative approach for this therapy. Our purpose was to investigate the feasibility, safety, and efficacy of percutaneous endoscopic electrodes for gastric electrical stimulation. Experimental animal study in hound dogs. Percutaneous endoscopic transgastric electrode (PETE) placement was carried out by using a pair of gastric pacing wires attached to a percutaneous endoscopic gastrostomy tube. In addition, 4 pairs of gastric serosal electrodes were implanted surgically for comparison. The efficacy of the percutaneous endoscopic electrodes was defined by their ability to entrain gastric slow waves and the induction of dysrhythmia. (1) The PETE recorded gastric slow waves comparable to the serosal electrodes. (2) Gastric electrical stimulation with long pulses delivered by the PETE, at a frequency of 10% higher than the intrinsic gastric slow wave frequency, entrained gastric slow waves. (3) Gastric electrical st...Continue Reading

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Citations

Jun 6, 2009·Drugs·Jing MaMichael Horowitz
Jan 22, 2011·World Journal of Gastroenterology : WJG·Mauro Bortolotti
Nov 3, 2009·Gastrointestinal Endoscopy·Gregory A Coté, Steven A Edmundowicz
Mar 4, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W L Hasler
Jun 25, 2015·Gastroenterology Research and Practice·Jason Behary, Vivek Kumbhari
Apr 14, 2016·Surgical Innovation·Davor ŠtimacMilan Ličina
Jan 14, 2017·Expert Review of Medical Devices·Sanja Klobucar MajanovicDavor Stimac
Jun 23, 2012·Digestive Diseases·Davor Stimac, Sanja Klobučar Majanović
Sep 4, 2009·Current Opinion in Gastroenterology·Jan Tack
Oct 25, 2011·Expert Review of Gastroenterology & Hepatology·Pietro FamiliariGuido Costamagna
Dec 17, 2015·World Journal of Hepatology·Naveen Kumar, Narendra Singh Choudhary
Jul 20, 2011·Nature Reviews. Gastroenterology & Hepatology·William L Hasler
Sep 6, 2011·The Surgical Clinics of North America·Jack W RostasWilliam O Richards

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